Metronidazol
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Orvagil, Metronidazol |
| Drugs.com | Monografija |
| Način primene | Oralno, intravaginalno, topikalno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 6-8 h |
| Identifikatori | |
| CAS broj | 443-48-1  |
| ATC kod | A01AB17 (WHO), P01AB01 |
| PubChem | CID 4173 |
| DrugBank | DB00916 |
| ChemSpider | 4029 |
| ChEBI | CHEBI:6909 |
| ChEMBL | CHEMBL137 |
| Hemijski podaci | |
| Formula | C6H9N3O3 |
| Molarna masa | 171,154 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | 1.605 °C (2.921 °F) |
Metronidazol je organsko jedinjenje, koje sadrži 6 atoma ugljenika i ima molekulsku masu od 171,154 Da.[1][2][3][4][5][6]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 3 |
| Particioni koeficijent[7] (ALogP) | -0,3 |
| Rastvorljivost[8] (logS, log(mol/L)) | -1,3 |
| Polarna površina[9] (PSA, Å2) | 83,9 |
Reference
[уреди | уреди извор]- ^ Shennan A, Crawshaw S, Briley A, Hawken J, Seed P, Jones G, Poston L (јануар 2006). „A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study.”. BJOG. 113 (1): 65—74. PMID 16398774. doi:10.1111/j.1471-0528.2005.00788.x.
- ^ Lamont, R. F. (март 2005). „Can antibiotics prevent preterm birth--the pro and con debate”. BJOG. 112 (Suppl. 1): 67—73. PMID 15715599. doi:10.1111/j.1471-0528.2005.00589.x.
- ^ Williams CS, Woodcock KR (фебруар 2000). „Do ethanol and metronidazole interact to produce a disulfiram-like reaction? Ann Pharmacother”. The Annals of Pharmacotherapy. 34 (2): 255—7. PMID 10676835. doi:10.1345/aph.19118.
- ^ Visapaa JP, Tillonen JS, Kaihovaara PS, Salaspuro MP (јун 2002). „Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother”. The Annals of Pharmacotherapy. 36 (6): 971—4. PMID 12022894. doi:10.1345/aph.1A066.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
