Spiramicin
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 8025-81-8  |
| ATC kod | J01FA02 (WHO) QJ51 |
| PubChem | CID 5356392 |
| ChemSpider | 4512090 |
| UNII | 71ODY0V87H |
| KEGG | D05908 |
| ChEMBL | CHEMBL1256397 |
| Sinonimi | 2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6[(2S,3R,4R,5S,6R)-5[(2S,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy10[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
| Hemijski podaci | |
| Formula | C43H74N2O14 |
| Molarna masa | 843,053 |
| |
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| Fizički podaci | |
| Rastvorljivost u vodi | Insoluble in water; Very soluble in acetonitrile and methanol; Almost completely(>99.5) in ethanol. mg/mL (20 °C) |
Spiramicin je organsko jedinjenje, koje sadrži 43 atoma ugljenika i ima molekulsku masu od 843,053 Da.
Osobine[уреди | уреди извор]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 16 |
| Broj donora vodonika | 4 |
| Broj rotacionih veza | 11 |
| Particioni koeficijent[1] (ALogP) | 2,0 |
| Rastvorljivost[2] (logS, log(mol/L)) | -5,8 |
| Polarna površina[3] (PSA, Å2) | 195,4 |
Reference[уреди | уреди извор]
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura[уреди | уреди извор]
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
