Tetrahidrokanabinolna kiselina
 | |
| IUPAC ime | |
|---|---|
(6aR,10aR)-1-hidroksi-6,6,9-trimetil-3-pentil-6a,7,8,10a-tetrahidro-6h-benzo[c]hromen-2-karboksilna kiselina | |
| Identifikatori | |
| CAS broj | 23978-85-0  |
| ATC kod | none |
| PubChem | CID 98523 |
| ChemSpider | 88974 |
| Hemijski podaci | |
| Formula | C22H30O4 |
| Molarna masa | 358,4733 g/mol |
| |
Tetrahidrokanabinolna kiselina (THCA, 2-COOH-THC) je biosintetički precursor tetrahidrokanabinola (THC), aktivne komponente kanabisa.[1][2][3][4] THCA je prisutan u varijabilnim količinama u svežem, neosušenom kanabisu, ali se progresiivno dekarboksiluje do THC tokom sušenja, a posebno tokom intezivnog zagrevanja, npr. pri pušenju kanabisa.[5]
Reference[уреди | уреди извор]
- ^ Baker PB, Taylor BJ, Gough TA (1981), „The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products”, Journal of Pharmacy and Pharmacology, 33 (6): 369—72, PMID 6115009
- ^ Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F (17. 9. 2004), „The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L.”, Journal of Biological Chemistry, 279 (38): 39767—74, PMID 15190053
- ^ Moore C, Rana S, Coulter C (1. 6. 2007), „Simultaneous identification of 2-carboxy-tetrahydrocannabinol, tetrahydrocannabinol, cannabinol and cannabidiol in oral fluid”, J Chromatogr B Analyt Technol Biomed Life Sci., 852 (1-2): 459—64, PMID 17321807
- ^ Taura F. (2009), „Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana”, Drug Discoveries and Therapeutics, 3 (3): 83—7, PMID 22495534
- ^ Dussy FE, Hamberg C, Luginbühl M, Schwerzmann T, Briellmann TA (2005-04-20), „Isolation of Delta9-THCA-A from hemp and analytical aspects concerning the determination of Delta9-THC in cannabis products”, Forensic Science International, 149 (1): 3—10, PMID 15734104
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