Tolonidin

Tolonidin
Nazivi
	IUPAC naziv N-(2-hloro-4-metilfenil)-4,5-dihidro-1H-imidazol-2-amin
Identifikacija
CAS broj	4201-22-3;
3D model (Jmol)	interaktivna slika;
KEGG	D07168 ;
PubChem C ID	72138;
	SMILES CC1=CC(=C(C=C1)NC2=NCCN2)Cl; ; ; ; ; ;
Svojstva
Hemijska formula	C10H12ClN3
Molarna masa	209,67538
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Tolonidin je antihipertenziv.^[4]^[5]^[6]

Reference[уреди | уреди извор]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate”. Arzneimittel-Forschung. 25 (10): 1557—1561. PMID 1243037.
^ Cosnier, D.; Labrid, C.; Rispat, G.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis”. Arzneimittel-Forschung. 25 (11): 1802—1806. PMID 1243090.
^ Cosnier, D.; Hache, J.; Labrid, C.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity”. Arzneimittel-Forschung. 25 (12): 1926—1933. PMID 3186.

Spoljašnje veze[уреди | уреди извор]

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate”. Arzneimittel-Forschung. 25 (10): 1557—1561. PMID 1243037.

[5] Cosnier, D.; Labrid, C.; Rispat, G.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis”. Arzneimittel-Forschung. 25 (11): 1802—1806. PMID 1243090.

[6] Cosnier, D.; Hache, J.; Labrid, C.; Streichenberger, G. (1975). „Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity”. Arzneimittel-Forschung. 25 (12): 1926—1933. PMID 3186.

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