Citrat (Si)-sintaza — разлика између измена

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| caption = Citrat sintaza hexamer, Burkholderia thailandensis
| caption = Citrat sintaza hexamer, Burkholderia thailandensis
}}
}}
'''Citrat (Si)-sintaza''' ({{EC broj-lat|2.3.3.1}}, ''(-{R}-)-limunska sintaza'', ''citrat kondenzujući enzim'', ''citrat oksaloacetatna lijaza ((pro-3-{S)-CH2COO}--->acetil-KoA)'', ''citrat oksaloacetatna lijaza, KoA-acetilacija'', ''citratna sintaza'', ''citratna sintetaza'', ''citrik sintaza'', ''citratni kondenzujući enzim'', ''citrogenaza'', ''kondenzujući enzim'', ''oksaloacetatna transacetaza'', ''oksalacetinska transacetaza'') je [[enzim]] sa sistematskim imenom ''acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formirane (pro--{S}-)-karboksimetila)''.<ref>{{cite journal | title = Partial purification and some properties of the (''R'')-citrate synthase from ''Clostridium acidi-urici'' |author = Gottschalk, G. |journal = Eur. J. Biochem. |date = 1969 |volume = 7 |pages = 301-306 |pmid = 4974734}}</ref><ref>{{cite journal | title = Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme |author = Ochoa, S., Stern, J.R. and Schneider, M.C. |journal = J. Biol. Chem. |date = 1951 |volume = 193 |pages = 691-702 |pmid = 14907759}}</ref><ref>{{Cite book | chapter = Oxalacetate transacetase (condensing enzyme, citrogenase) | title = The Enzymes |author = Stern, J.R. |date = 1961 |volume = 5 |pages = 367-380 |editor = Boyer, P,D., Lardy, H and Myrb&auml;ck, K. |edition = 2nd |publisher = Academic Press |location = New York }}</ref><ref>{{cite journal | title = ''Azotobacter vinelandii'' citrate synthase |author = Rault-Leonardon, M., Atkinson, M.A., Slaughter, C.A., Moomaw, C.R. and Srere, P.A. |journal = Biochemistry |date = 1995 |volume = 34 |pages = 257-263 |pmid = 7819205}}</ref><ref>{{cite journal | title = Citrate synthase from the hyperthermophilic Archaeon, ''Pyrococcus furiosus'' |author = Muir, J.M., Russell, R.J., Hough, D.W. and Danson, M.J. |journal = Prot. Eng. |date = 1995 |volume = 8 |pages = 583-592 |pmid = 8532683}}</ref><ref>{{cite journal | title = The crystal structure of citrate synthase from the hyperthermophilic archaeon ''Pyrococcus furiosus'' at 1.9 &Aring; resolution |author = Russell, R.J., Ferguson, J.M., Hough, D.W., Danson, M.J. and Taylor, G.L. |journal = Biochemistry |date = 1997 |volume = 36 |pages = 9983-9994 |pmid = 9254593}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]
'''Citrat (Si)-sintaza''' ({{EC broj-lat|2.3.3.1}}, ''(-{R}-)-limunska sintaza'', ''citrat kondenzujući enzim'', ''citrat oksaloacetatna lijaza ((pro-3-{S)-CH2COO}--->acetil-KoA)'', ''citrat oksaloacetatna lijaza, KoA-acetilacija'', ''citratna sintaza'', ''citratna sintetaza'', ''citrik sintaza'', ''citratni kondenzujući enzim'', ''citrogenaza'', ''kondenzujući enzim'', ''oksaloacetatna transacetaza'', ''oksalacetinska transacetaza'') je [[enzim]] sa sistematskim imenom ''acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formirane (pro--{S}-)-karboksimetila)''.<ref>{{cite journal | title = Partial purification and some properties of the (''R'')-citrate synthase from ''Clostridium acidi-urici'' |author = Gottschalk, G. |journal = Eur. J. Biochem. |date = 1969 |volume = 7 |pages = 301-306 |pmid = 4974734}}</ref><ref>{{cite journal | title = Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme |author = Ochoa, S., Stern, J.R. and Schneider, M.C. |journal = J. Biol. Chem. |date = 1951 |volume = 193 |pages = 691-702 |pmid = 14907759}}</ref><ref>{{Cite book | chapter = Oxalacetate transacetase (condensing enzyme, citrogenase) | title = The Enzymes |author = Stern, J.R. |date = 1961 |volume = 5 |pages = 367-380 |editor1=Boyer, P,D., Lardy, H |editor2=Myrb |editor3=auml |editor4=ck, K. |edition = 2nd |publisher = Academic Press |location = New York }}</ref><ref>{{cite journal | title = ''Azotobacter vinelandii'' citrate synthase |author = Rault-Leonardon, M., Atkinson, M.A., Slaughter, C.A., Moomaw, C.R. and Srere, P.A. |journal = Biochemistry |date = 1995 |volume = 34 |pages = 257-263 |pmid = 7819205}}</ref><ref>{{cite journal | title = Citrate synthase from the hyperthermophilic Archaeon, ''Pyrococcus furiosus'' |author = Muir, J.M., Russell, R.J., Hough, D.W. and Danson, M.J. |journal = Prot. Eng. |date = 1995 |volume = 8 |pages = 583-592 |pmid = 8532683}}</ref><ref>{{cite journal | title = The crystal structure of citrate synthase from the hyperthermophilic archaeon ''Pyrococcus furiosus'' at 1.9 &Aring; resolution |author = Russell, R.J., Ferguson, J.M., Hough, D.W., Danson, M.J. and Taylor, G.L. |journal = Biochemistry |date = 1997 |volume = 36 |pages = 9983-9994 |pmid = 9254593}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]


: [[acetil-KoA]] + -{H}-<sub>2</sub>O + oksaloacetat <math>\rightleftharpoons</math> [[citrat]] + KoA
: [[acetil-KoA]] + -{H}-<sub>2</sub>O + oksaloacetat <math>\rightleftharpoons</math> [[citrat]] + KoA
Ред 19: Ред 19:


== Литература ==
== Литература ==
* {{Cite book |ref= harv|chapter = Oxalacetate transacetase (condensing enzyme, citrogenase) | title = The Enzymes |author = Stern, J.R. |date = 1961 |volume = 5 |pages = 367-380 |editor = Boyer, P,D., Lardy, H and Myrb&auml;ck, K. |edition = 2nd |publisher = Academic Press |location = New York }}
* {{Cite book |ref= harv|chapter = Oxalacetate transacetase (condensing enzyme, citrogenase) | title = The Enzymes |author = Stern, J.R. |date = 1961 |volume = 5 |pages = 367-380 |editor1=Boyer, P,D., Lardy, H |editor2=Myrb |editor3=auml |editor4=ck, K. |edition = 2nd |publisher = Academic Press |location = New York }}


== Spoljašnje veze ==
== Spoljašnje veze ==

Верзија на датум 24. октобар 2016. у 02:35

Citrat (Si)-sintaza
Citrat sintaza hexamer, Burkholderia thailandensis
Identifikatori
EC broj2.3.3.1
CAS broj9027-96-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Citrat (Si)-sintaza (EC 2.3.3.1, (R)-limunska sintaza, citrat kondenzujući enzim, citrat oksaloacetatna lijaza ((pro-3S)-CH2COO-->acetil-KoA), citrat oksaloacetatna lijaza, KoA-acetilacija, citratna sintaza, citratna sintetaza, citrik sintaza, citratni kondenzujući enzim, citrogenaza, kondenzujući enzim, oksaloacetatna transacetaza, oksalacetinska transacetaza) je enzim sa sistematskim imenom acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formirane (pro-S)-karboksimetila).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + H2O + oksaloacetat citrat + KoA

Stereospecifičnost ovog enzima je suprotna enzimu EC 2.3.3.3, citrat (Re)-sintazi, koji je nađen kod nekoliko anaerobih vrsta.

Reference

  1. ^ Gottschalk, G. (1969). „Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici”. Eur. J. Biochem. 7: 301—306. PMID 4974734. 
  2. ^ Ochoa, S., Stern, J.R. and Schneider, M.C. (1951). „Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme”. J. Biol. Chem. 193: 691—702. PMID 14907759. 
  3. ^ Stern, J.R. (1961). „Oxalacetate transacetase (condensing enzyme, citrogenase)”. Ур.: Boyer, P,D., Lardy, H; Myrb; auml; ck, K. The Enzymes. 5 (2nd изд.). New York: Academic Press. стр. 367—380. 
  4. ^ Rault-Leonardon, M., Atkinson, M.A., Slaughter, C.A., Moomaw, C.R. and Srere, P.A. (1995). „Azotobacter vinelandii citrate synthase”. Biochemistry. 34: 257—263. PMID 7819205. 
  5. ^ Muir, J.M., Russell, R.J., Hough, D.W. and Danson, M.J. (1995). „Citrate synthase from the hyperthermophilic Archaeon, Pyrococcus furiosus”. Prot. Eng. 8: 583—592. PMID 8532683. 
  6. ^ Russell, R.J., Ferguson, J.M., Hough, D.W., Danson, M.J. and Taylor, G.L. (1997). „The crystal structure of citrate synthase from the hyperthermophilic archaeon Pyrococcus furiosus at 1.9 Å resolution”. Biochemistry. 36: 9983—9994. PMID 9254593. 

Литература

  • Stern, J.R. (1961). „Oxalacetate transacetase (condensing enzyme, citrogenase)”. Ур.: Boyer, P,D., Lardy, H; Myrb; auml; ck, K. The Enzymes. 5 (2nd изд.). New York: Academic Press. стр. 367—380. 

Spoljašnje veze

Преузето из „https://sr.wikipedia.org/w/index.php?title=Citrat_(Si)-sintaza&oldid=12148101”