(Heparan sulfat)-glukozamin N-sulfotransferaza
| (heparan sulfat)-glukozamin N-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.8 | ||||||||
| CAS broj | 9026-75-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(heparan sulfat)-glukozamin N-sulfotransferaza (EC 2.8.2.8, heparinska N-sulfotransferaza, 3'-fosfoadenililsulfat:N-desulfoheparin sulfotransferaza, PAPS:N-desulfoheparin sulfotransferaza, PAPS:DSH sulfotransferaza, N-HSST, N-heparan sulfatna sulfotransferaza, heparan sulfat N-deacetilase/N-sulfotransferaza, heparan sulfatna 2-N-sulfotransferaza, heparan sulfatna N-sulfotransferaza, heparan sulfatna sulfotransferaza, N-desulfoheparinska sulfotransferaza, desulfoheparinska sulfotransferaza, 3'-fosfoadenilil-sulfat:N-desulfoheparin N-sulfotransferaza, heparitinska sulfotransferaza, 3'-fosfoadenilil-sulfat:heparitin N-sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin N-sulfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-N-sulfoglukozamin
Ovaj enzim takođe katalizuje sulfaciju hondroitin 4-sulfata i dermatan sulfata.
Reference[уреди | уреди извор]
- ^ Suzuki, S., Trenn, R.H. and Strominger, J.L. (1961). „Separation of specific mucopolysaccharide sulfotransferases”. Biochim. Biophys. Acta. 50: 169—174.
- ^ Eisenman, R.A., Balasubramanian, A.S. and Marx, W. (1967). „3′-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction”. Arch. Biochem. Biophys. 119: 387—397. PMID 4964017.
- ^ Johnson, A.H. & Baker, J.R. (1973). „The enzymatic sulphation of heparan sulphate by hen's uterus”. Biochim. Biophys. Acta. 320: 341—351. PMID 4270798.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- (heparan+sulfate)-glucosamine+N-sulfotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
