2-Hidroksi-dATP difosfataza
(преусмерено са 2-hidroksi-dATP difosfataza)
| 2-Hidroksi-dATP difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.56 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Hidroksi-dATP difosfataza (EC 3.6.1.56, NUDT1, MTH1, MTH2, oksidovana purinska nukleozidna trifosfataza, (2'-dezoksi) ribonukleozidna 5'-trifosfatna pirofosfohidrolaza) je enzim sa sistematskim imenom 2-hidroksi-dATP difosfohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-hidroksi-dATP + H2O 2-hidroksi-dAMP + difosfat
Ovaj enzim hidrolizuje oksidovane purinske nukleozidne trifosfate.
Reference[уреди | уреди извор]
- ^ Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H. and Sekiguchi, M. (1993). „Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis”. J. Biol. Chem. 268: 23524—23530. PMID 8226881.
- ^ Kakuma, T., Nishida, J., Tsuzuki, T. and Sekiguchi, M. (1995). „Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution”. J. Biol. Chem. 270: 25942—25948. PMID 7592783.
- ^ Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y. and Kasai, H. (1999). „The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein”. J. Biol. Chem. 274: 18201—18205. PMID 10373420.
- ^ Sakai, Y., Furuichi, M., Takahashi, M., Mishima, M., Iwai, S., Shirakawa, M. and Nakabeppu, Y. (2002). „A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1”. J. Biol. Chem. 277: 8579—8587. PMID 11756418.
- ^ Fujikawa, K., Kamiya, H., Yakushiji, H., Nakabeppu, Y. and Kasai, H. (2001). „Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP”. Nucleic Acids Res. 29: 449—454. PMID 11139615.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 2-hydroxy-dATP+diphosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
