5-(Karboksiamino)imidazolna ribonukleotid mutaza

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5-(Karboksiamino)imidazolna ribonukleotid mutaza
Identifikatori
EC broj5.4.99.18
CAS broj255379-40-9
Baze podataka
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Strukture PBPRCSB PDB PDBe PDBsum

5-(Karboksiamino)imidazolna ribonukleotid mutaza (EC 5.4.99.18, N5-CAIR mutaza, PurE, N5-karboksiaminoimidazol ribonukleotidna mutaza, klasa I PurE) je enzim sa sistematskim imenom 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol karboksimutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat

Kod eubakterija, gljiva i biljiki, ovaj enzim, zajedno sa EC 6.3.4.18, 5-(karboksiamino)imidazol ribonukleotidnom sintazom, je nephodan za izvođenje reakcije koju katalizuje enzim EC 4.1.1.21, fosforibozilaminoimidazolna karboksilaza, kod kičmenjaka.

Reference[уреди]

  1. ^ Meyer, E., Leonard, N.J., Bhat, B., Stubbe, J. and Smith, J.M. (1992). „Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry. 31: 5022—5032. PMID 1534690. 
  2. ^ Mueller, E.J., Meyer, E., Rudolph, J., Davisson, V.J. and Stubbe, J. (1994). „N5-Carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry. 33: 2269—2278. PMID 8117684. 
  3. ^ Meyer, E., Kappock, T.J., Osuji, C. and Stubbe, J. (1999). „Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase”. Biochemistry. 38: 3012—3018. PMID 10074353. 
  4. ^ Mathews, I.I., Kappock, T.J., Stubbe, J. and Ealick, S.E. (1999). „Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway”. Structure. 7: 1395—1406. PMID 10574791. 
  5. ^ Firestine, S.M., Poon, S.W., Mueller, E.J., Stubbe, J. and Davisson, V.J. (1994). „Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms”. Biochemistry. 33: 11927—11934. PMID 7918411. 
  6. ^ Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R. and Davisson, V.J. (1998). „Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis”. Arch. Biochem. Biophys. 351: 123—134. PMID 9500840. 

Literatura[уреди]

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