5-HT1D receptor

Из Википедије, слободне енциклопедије
5-hidroksitriptaminski (serotoninski) receptor 1D
Identifikatori
Simboli HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
Vanjski ID OMIM182133 MGI96276 HomoloGene20240 IUPHAR: 5-HT1D GeneCards: HTR1D Gene
Pregled RNK izražavanja
PBB GE HTR1D 207368 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3352 15552
Ensembl ENSG00000179546 ENSMUSG00000070687
UniProt P28221 Q3ZB48
RefSeq (mRNA) NM_000864 NM_008309
RefSeq (protein) NP_000855 NP_032335
Lokacija (UCSC) Chr 1:
23.39 - 23.39 Mb
Chr 4:
135.7 - 135.72 Mb
PubMed pretraga [1] [2]

5-HT1D receptor (5-hidroksitriptaminski (serotoninski) receptor 1D, HTR1D) je 5-HT receptor. On je kodiran istoimenim genom.[1] 5-HT1D deluje na centralni nervni sistem, i utiče na kretanje i anksioznost. On takoše indukuje vaskularnu vazokonstrikciju u mozgu.

Ligandi[уреди]

Agonisti[уреди]

  • 5-(Noniloksi)triptamin,[2]
  • sumatriptan (vazokonstriktor kod migraine)
  • 5-Karboksamidotriptamin (5-CT)
  • 5-(t-Butil)-N-metiltriptamin[3]
  • CP-286,601
  • PNU-109,291 ((S)-3,4-Dihidro-1-[2-[4-(4-metoksifenil)-1-piperazinil]etil]-N-metil-1H-2-benzopiran-6-karboksamid)
  • PNU-142,633 ((1S)-1-[2-[4-[4-(Aminokarbonil)fenil]-1-piperazinil]etil]-3,4-dihidro-N-metil-1H-2-benzopiran-6-karboksamid)
  • GR-46611 (3-[3-(2-Dimetilaminoetil)-1H-indol-5-il]-N-(4-metoksibenzil)akrilamid)
  • L-694,247 (2-[5-[3-(4-Metilsulfonilamino)benzil-1,2,4-oksadiazol-5-il]-1H-indol-3-il]etanamin)
  • L-772,405

Antagonisti

Vidi još[уреди]

Literatura[уреди]

  1. „Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D”. 
  2. Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). „5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist”. J. Med. Chem. 37 (18): 2828—30. doi:10.1021/jm00044a001. PMID 8071931. 
  3. Xu, YC; Schaus, JM; Walker, C; Krushinski, J; Adham, N; Zgombick, JM; Liang, SX; Kohlman, DT; Audia, JE (1999). „N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.”. Journal of medicinal chemistry 42 (3): 526—31. doi:10.1021/jm9805945. PMID 9986723. 
  4. „Essential psychopharmacology: neuroscientific basis and practical applications”. 

Dodatna literatura[уреди]

  • Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). „Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.”. Biochem. Biophys. Res. Commun. 184 (2): 752—9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531. 
  • Weinshank RL, Zgombick JM, Macchi MJ; et al. (1992). „Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.”. Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630—4. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658. 
  • Hamblin MW, Metcalf MA (1991). „Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.”. Mol. Pharmacol. 40 (2): 143—8. PMID 1652050. 
  • Libert F, Passage E, Parmentier M; et al. (1992). „Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.”. Genomics 11 (1): 225—7. doi:10.1016/0888-7543(91)90125-X. PMID 1662665. 
  • Libert F, Parmentier M, Lefort A; et al. (1989). „Selective amplification and cloning of four new members of the G protein-coupled receptor family.”. Science 244 (4904): 569—72. doi:10.1126/science.2541503. PMID 2541503. 
  • Cargill M, Altshuler D, Ireland J; et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes.”. Nat. Genet. 22 (3): 231—8. doi:10.1038/10290. PMID 10391209. 
  • Salim K, Fenton T, Bacha J; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.”. J. Biol. Chem. 277 (18): 15482—5. doi:10.1074/jbc.M201539200. PMID 11854302. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Bergen AW, van den Bree MB, Yeager M; et al. (2004). „Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.”. Mol. Psychiatry 8 (4): 397—406. doi:10.1038/sj.mp.4001318. PMID 12740597. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173—8. doi:10.1038/nature04209. PMID 16189514. 
  • Gregory SG, Barlow KF, McLay KE; et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315—21. doi:10.1038/nature04727. PMID 16710414. 
  • Li J, Zhang X, Wang Y; et al. (2007). „The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (8): 874—6. doi:10.1002/ajmg.b.30364. PMID 17099886. 

Spoljašnje veze[уреди]

  • „5-HT1D. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.