5-MeO-NBpBrT

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5-MeO-NBpBrT
5-MeO-NBpBrT structure.png
IUPAC ime
N-(4-Bromobenzil)-2-(5-metoksi-1H-indol-3-il)etanamin
Identifikatori
ATC kodnone
PubChemCID 5124753
ChemSpider4299315 ДаY
ChEMBLCHEMBL57427 ДаY
Hemijski podaci
FormulaC18H19BrN2O
Molarna masa359,260 g/mol

5-MeO-NBpBrT (5-Metoksi-N-(4-bromobenzil)triptamin) je lek koji deluje kao antagonist za 5-HT2A receptor,[1] koji je sto puta selektivniji za taj receptor u odnosu na blisko srodni 5-HT2C receptor.[2][3][4]

Reference[уреди]

  1. ^ Niels Jensen. Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens. PhD dissertation, Georg-August-Universität zu Göttingen, 2004.
  2. ^ Glennon RA, Dukat M, el-Bermawy M, Law H, De los Angeles J, Teitler M, King A, Herrick-Davis K. Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. Journal of Medicinal Chemistry. 1994 Jun 24;37(13):1929-35. PMID 8027974
  3. ^ Maria Silva PhD. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
  4. ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design. 25 (1): 51—66. PMID 21088982. doi:10.1007/s10822-010-9400-2. 

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