8-Fenilteofilin

Из Википедије, слободне енциклопедије
8-Fenilteofilin
8-Phenyltheophylline.png
IUPAC ime
8-fenil-1,3-dimetil-7H-purin-2,6-dion
Identifikatori
CAS broj 961-45-5 ДаY
ATC kod none
PubChem CID 1922
ChemSpider 1846 ДаY
ChEMBL CHEMBL62350 ДаY
Hemijski podaci
Formula C13H12N4O2
Molarna masa 256,259 g/mol
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8-Fenilteofilin (8-fenil-1,3-dimetilksantin, 8-PT) je lek iz ksantinske familije koji deluje kao potentan i selektivan antagonist adenozinskih receptora A1 i A2A, ali za razliku od drugih derivata ksantina on nije inhibitor fosfodiesteraze.[1][2][3] On ima stimulantno dejstvo u životinjskim studijama i sličnu potentnost sa kofeinom.[4] 8-Fenilteofilin je isto tako potentan i selektivan inhibitor jetrenog enzima CYP1A2 zbog čeka je verovatno da uzrokuje nepoželjne interakcije sa drugim lekovima koje CYP1A2 normalno metaboliše.[5]

Reference[уреди]

  1. Scotini E, Carpenedo F, Fassina G (1983). „New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities”. Pharmacological Research Communications. 15 (2): 131—43. PMID 6844374. 
  2. Rabe KF, Magnussen H, Dent G (1995). „Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants”. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology. 8 (4): 637—42. PMID 7664866. 
  3. Howell LL, Morse WH, Spealman RD (1990). „Respiratory effects of xanthines and adenosine analogs in rhesus monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 254 (3): 786—91. PMID 2395111. 
  4. Spealman RD (1988). „Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism”. Psychopharmacology. 95 (1): 19—24. PMID 3133696. 
  5. Murray S, Odupitan AO, Murray BP, Boobis AR, Edwards RJ (2001). „Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline”. Xenobiotica. 31 (3): 135—51. doi:10.1080/00498250110043292. PMID 11465391. 

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