Aciloksiacilna hidrolaza
(преусмерено са Aciloksiacil hidrolaza)
| Aciloksiacilna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.77 | ||||||||
| CAS broj | 110277-64-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aciloksiacilna hidrolaza (EC 3.1.1.77) je enzim sa sistematskim imenom '.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-(aciloksi)acil grupa bakterijskog toksina + H2O 3-hidroksiacil grupa bakterijskog toksina + masna kiselina
Supstrat je lipid A na redukujućem kraju toksičnog lipopolisaharida (LPS) u bakteriji Salmonella typhimurium i srodnim organizmima.
Reference[уреди | уреди извор]
- ^ Erwin, A.L. & Munford, R.S. (1990). „Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase”. J. Biol. Chem. 265: 16444—16449. PMID 2398058.
- ^ Hagen, F.S., Grant, F.J., Kuijper, J.L., Slaughter, C.A., Moomaw, C.R., Orth, K., O'Hara, P.J. and Munford, R.S. (1991). „Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides”. Biochemistry. 30: 8415—8423. PMID 1883828.
- ^ Munford, R.S. & Hunter, J.P. (1992). „Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro”. J. Biol. Chem. 267: 10116—10121. PMID 1577781.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Acyloxyacyl+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
