Aktinomicin

Aktinomicin
Klinički podaci
Prodajno ime	Chounghwamycin B, Cosmegen, Lyovac Cosmegen, Meractinomycin
Drugs.com	Monografija
Način primene	Intravenozno
Identifikatori
CAS broj	50-76-0
ATC kod	L01DA01 (WHO)
PubChem	CID 2019
DrugBank	DB00970
ChemSpider	10482167
KEGG	C06770
ChEBI	CHEBI:27666
ChEMBL	CHEMBL1554

Aktinomicin je organsko jedinjenje, koje sadrži 62 atoma ugljenika i ima molekulsku masu od 1255,417 Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	18
Broj donora vodonika	5
Broj rotacionih veza	8
Particioni koeficijent^[7] (ALogP)	0,4
Rastvorljivost^[8] (logS, log(mol/L))	-10,8
Polarna površina^[9] (PSA, Å²)	355,5

Reference

^ Sobell HM: Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. Sobell, H. M. (1985 Aug). „Actinomycin and DNA transcription”. Proceedings of the National Academy of Sciences of the United States of America. 82 (16): 5328—31. Bibcode:1985PNAS...82.5328S. PMC 390561 . PMID 2410919. doi:10.1073/pnas.82.16.5328 . Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Turan T, Karacay O, Tulunay G, Boran N, Koc S, Bozok S, Kose MF: Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2006 May-Jun;Turan, T.; Karacay, O.; Tulunay, G.; Boran, N.; Koc, S.; Bozok, S.; Kose, M. F. (2006). „Results with EMA/CO (Etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia”. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 16 (3): 1432—8. PMID 16803542. doi:10.1111/j.1525-1438.2006.00606.x.
^ Abd El-Aal HH, Habib EE, Mishrif MM: Wilms' tumor: the experience of the pediatric unit of Kasr El-Aini center of radiation oncology and nuclear medicine (NEMROCK). J Egypt Natl Canc Inst. 2005 Dec; Abd El-Aal, H. H.; Habib, E. E.; Mishrif, M. M. (2005). „Wilms' tumor: The experience of the pediatric unit of Kasr El-Aini center of radiation oncology and nuclear medicine (NEMROCK)”. Journal of the Egyptian National Cancer Institute. 17 (4): 308—14. PMID 17102824.
^ Khatua S, Nair CN, Ghosh K: Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: the unresolved issues. J Pediatr Hematol Oncol. Khatua, S.; Nair, C. N.; Ghosh, K. (2004 Nov). „Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: The unresolved issues”. Journal of Pediatric Hematology/Oncology. 26 (11): 777—9. PMID 15543019. doi:10.1097/00043426-200411000-00020. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Actinomycin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Sobell HM: Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. Sobell, H. M. (1985 Aug). „Actinomycin and DNA transcription”. Proceedings of the National Academy of Sciences of the United States of America. 82 (16): 5328—31. Bibcode:1985PNAS...82.5328S. PMC 390561 . PMID 2410919. doi:10.1073/pnas.82.16.5328 . Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Turan T, Karacay O, Tulunay G, Boran N, Koc S, Bozok S, Kose MF: Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2006 May-Jun;Turan, T.; Karacay, O.; Tulunay, G.; Boran, N.; Koc, S.; Bozok, S.; Kose, M. F. (2006). „Results with EMA/CO (Etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia”. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 16 (3): 1432—8. PMID 16803542. doi:10.1111/j.1525-1438.2006.00606.x.

[3] Abd El-Aal HH, Habib EE, Mishrif MM: Wilms' tumor: the experience of the pediatric unit of Kasr El-Aini center of radiation oncology and nuclear medicine (NEMROCK). J Egypt Natl Canc Inst. 2005 Dec; Abd El-Aal, H. H.; Habib, E. E.; Mishrif, M. M. (2005). „Wilms' tumor: The experience of the pediatric unit of Kasr El-Aini center of radiation oncology and nuclear medicine (NEMROCK)”. Journal of the Egyptian National Cancer Institute. 17 (4): 308—14. PMID 17102824.

[4] Khatua S, Nair CN, Ghosh K: Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: the unresolved issues. J Pediatr Hematol Oncol. Khatua, S.; Nair, C. N.; Ghosh, K. (2004 Nov). „Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: The unresolved issues”. Journal of Pediatric Hematology/Oncology. 26 (11): 777—9. PMID 15543019. doi:10.1097/00043426-200411000-00020. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[7] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[8] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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