Alaninska aminopeptidaza

Из Википедије, слободне енциклопедије
Alaninska aminopeptidaza
Identifikatori
EC broj 3.4.11.2
CAS broj 9054-63-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Alaninska aminopeptidaza‎
Dostupne strukture
4FYQ, 4FYR, 4FYS, 4FYT
Identifikatori
Simboli ANPEP; APN; CD13; GP150; LAP1; P150; PEPN
Vanjski ID OMIM151530 MGI96749 HomoloGene68163 GeneCards: ANPEP Gene
EC broj 3.4.11.2
Pregled RNK izražavanja
PBB GE ANPEP 202888 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 290 16790
Ensembl ENSG00000166825 ENSMUSG00000039062
UniProt P15144 P97449
RefSeq (mRNA) NM_001150.2 NM_008486.2
RefSeq (protein) NP_001141.2 NP_032512.2
Lokacija (UCSC) Chr 15:
90.33 - 90.36 Mb
Chr 7:
79.82 - 79.85 Mb
PubMed pretraga [1] [2]

Alaninska aminopeptidaza (EC 3.4.11.2) je enzim koji se koristi kao biomarker za detekciju oštećenja bubrega. On se može koristiti u dijagnozi pojedinih tipova bubrežnih poremećaja. Ona je prisutna u visokim nivoima u urinu, kad postoji problem sa bubrezima.

Aminopeptidaza N je locirana u malim crevima i renalnoj mikrovilarnoj membrani, kao i drugim ćelijskim membranama. U tankim crevima aminopeptidaza N učestvuje u finalnom stupnju varenja peptida generisanih hidrolizom proteina gastričnim i pankreatičkim proteazama. Njena funkcija u epitelu i drugim tipovima ćelija nije potpuno razjašnjena. Veliki ekstracelularni karboksiterminalni domen sadrži pentapeptidnu konsenzus sekvencu koja je karakteristična za članove zink-vezujuće metaloproteinazne superfamilije. Poređenjem sekvence sa poznatim enzimima ove klase je pokazalo da su CD13 i aminopeptidaza N identični.[1]

Reference[уреди]

Literatura[уреди]

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Spoljašnje veze[уреди]