Alfa-1B adrenergički receptor

Из Википедије, слободне енциклопедије
Adrenergički alfa-1B receptor
Identifikatori
Simboli ADRA1B; ADRA1; ALPHA1BAR
Vanjski ID OMIM104220 MGI104774 HomoloGene55477 IUPHAR: α1B-adrenoceptor GeneCards: ADRA1B Gene
Pregled RNK izražavanja
PBB GE ADRA1B 207589 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 147 11548
Ensembl ENSG00000170214 ENSMUSG00000050541
UniProt P35368 Q05D47
RefSeq (mRNA) NM_000679 NM_007416
RefSeq (protein) NP_000670 NP_031442
Lokacija (UCSC) Chr 5:
159.28 - 159.33 Mb
Chr 11:
43.62 - 43.74 Mb
PubMed pretraga [1] [2]

Alfa-1B adrenergički receptor (α1B adrenoreceptor, ADRA1B), je alfa-1 adrenergički receptor, kodiran ADRA1B humanim genom.[1]

Receptor[уреди]

Postoje 3 tipa alfa-1 adrenergičkog receptora: alfa-1A, -1B i -1D. Svi oni prenose signal kroz Gq/11 familiju G-proteina. Različiti tipovi pokazuju različite oblike aktivacije. Oni aktiviraju mitogene response i regulišu rast i proliferaciju mnogih ćelija.

Gen[уреди]

Ovaj gen kodira alfa-1B-adrenergički receptor, koji indukuje neoplastičnu transformaciju kad se transfektira u NIH 3T3 fibroblaste i druge ćelijske linije. Iz tog razloga je ovaj normalni ćelijski gen identifikovan kao protoonkogen. On se sastoji od 2 iRNK eksona i jednog velikog introna sa najmanje 20 kb.[1]

Interakcije[уреди]

Za alfa-1B adrenergički receptor je pokazano da interaguje sa AP2M1.[2] Takođe se smatra da ima ulogu u dopaminergičkoj neurotransmisiji.[3][4]

Vidi još[уреди]

Literatura[уреди]

  1. 1,0 1,1 „Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor”. 
  2. Diviani, Dario; Lattion Anne-Laure, Abuin Liliane, Staub Olivier, Cotecchia Susanna (2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis”. J. Biol. Chem. (United States) 278 (21): 19331—40. doi:10.1074/jbc.M302110200. ISSN 0021-9258. PMID 12644451. 
  3. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (2002). „Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates”. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22 (7): 2873—84. PMID 11923452. 
  4. Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (2004). „5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants”. The European Journal of Neuroscience 20 (11): 3073—84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. 

Dodatna literatura[уреди]

  • Ramarao CS, Denker JM, Perez DM; et al. (1992). „Genomic organization and expression of the human alpha 1B-adrenergic receptor.”. J. Biol. Chem. 267 (30): 21936—45. PMID 1328250. 
  • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). „G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.”. Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354—8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393. 
  • Lomasney JW, Cotecchia S, Lorenz W; et al. (1991). „Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.”. J. Biol. Chem. 266 (10): 6365—9. PMID 1706716. 
  • Yang-Feng TL, Xue FY, Zhong WW; et al. (1990). „Chromosomal organization of adrenergic receptor genes.”. Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516—20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750. 
  • Schwinn DA, Johnston GI, Page SO; et al. (1995). „Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.”. J. Pharmacol. Exp. Ther. 272 (1): 134—42. PMID 7815325. 
  • Weinberg DH, Trivedi P, Tan CP; et al. (1994). „Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.”. Biochem. Biophys. Res. Commun. 201 (3): 1296—304. doi:10.1006/bbrc.1994.1845. PMID 8024574. 
  • Forray C, Bard JA, Wetzel JM; et al. (1994). „The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.”. Mol. Pharmacol. 45 (4): 703—8. PMID 8183249. 
  • Diviani D, Lattion AL, Larbi N; et al. (1996). „Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor.”. J. Biol. Chem. 271 (9): 5049—58. doi:10.1074/jbc.271.9.5049. PMID 8617782. 
  • Diviani D, Lattion AL, Cotecchia S (1997). „Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor.”. J. Biol. Chem. 272 (45): 28712—9. doi:10.1074/jbc.272.45.28712. PMID 9353340. 
  • Qian A, Wang W, Sanborn BM (1998). „Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).”. Cell. Signal. 10 (2): 101—5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484. 
  • Sasaguri T, Teruya H, Ishida A; et al. (2000). „Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells.”. Biochem. Biophys. Res. Commun. 268 (1): 25—30. doi:10.1006/bbrc.1999.2066. PMID 10652206. 
  • Minneman KP, Lee D, Zhong H; et al. (2000). „Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.”. J. Neurochem. 74 (6): 2392—400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
  • Shibata K, Katsuma S, Koshimizu T; et al. (2003). „alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.”. J. Biol. Chem. 278 (1): 672—8. doi:10.1074/jbc.M201375200. PMID 12409310. 
  • Diviani D, Lattion AL, Abuin L; et al. (2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.”. J. Biol. Chem. 278 (21): 19331—40. doi:10.1074/jbc.M302110200. PMID 12644451. 
  • Gonzalez-Cabrera PJ, Gaivin RJ, Yun J; et al. (2003). „Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130.”. Mol. Pharmacol. 63 (5): 1104—16. doi:10.1124/mol.63.5.1104. PMID 12695539. 
  • Pupo AS, Minneman KP (2004). „Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.”. J. Recept. Signal Transduct. Res. 23 (2-3): 185—95. doi:10.1081/RRS-120025200. PMID 14626446. 
  • Hague C, Uberti MA, Chen Z; et al. (2004). „Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.”. J. Biol. Chem. 279 (15): 15541—9. doi:10.1074/jbc.M314014200. PMID 14736874. 
  • Kang SK, Yi KS, Kwon NS; et al. (2004). „Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits.”. J. Biol. Chem. 279 (35): 36593—600. doi:10.1074/jbc.M402084200. PMID 15220331. 
  • Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). „Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.”. Endocrinology 145 (11): 5157—67. doi:10.1210/en.2004-0728. PMID 15297446. 
  • Zhang T, Xu Q, Chen FR; et al. (2005). „Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.”. Acta Pharmacol. Sin. 25 (11): 1471—8. PMID 15525470. 

Spoljašnje veze[уреди]

  • „α1B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.