Aspergilopepsin-I
| Aspergilopepsin-I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.18 | ||||||||
| CAS broj | 9025-49-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aspergilopepsin-I (EC 3.4.23.18, Aspergillus kiselinska proteaza, Aspergillus kiselinska proteinaza, Aspergillus aspartinska proteinaza, Aspergillus awamori kiselinska proteinaza, Aspergillus karboksilna proteinaza, karboksilna proteinaza, Aspergillus kawachii aspartinska proteinaza, Aspergillus saitoi kiselinska proteinaza, pepsin-tip aspartinska proteinaza, Aspergillus niger kiselinska proteinaza, sumizim AP, proktaza P, denapsin, denapsin XP 271, proktaza) je enzim.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću. Generalno postoji preferencija za hidrofobne ostatke u P1 i P1', mada Lys može da bude u P1. Dolazi do aktivacije tripsinogena. Ne dolazi do zgrušavanja mleka
Ovaj enzim je prisutan u mnoštvu Aspergillus vrsta.
Reference[уреди | уреди извор]
- ^ Kovaleva, G.G., Shimanskaya, M.P. and Stepanov, V.M. (1972). „The site of diazoacetyl inhibitor attachment to acid proteinase of Aspergillus awamori - an analog of penicillopepsin and pepsin”. Biochem. Biophys. Res. Commun. 49: 1075—1082. PMID 4565799.
- ^ Morihara, K. & Oka, T. (1973). „Comparative specificity of microbial acid proteinases for synthetic peptides. III. Relationship with their trypsinogen activating ability”. Arch. Biochem. Biophys. 157: 561—572. PMID 4593189.
- ^ Davidson, R., Gertler, A. and Hofmann, T. (1975). „Aspergillus oryzae' acid proteinase. Purification and properties, and formation of π-chymotrypsin”. Biochem. J. 147: 45—53. PMID 239702.
- ^ Chang, W.-J., Horiuchi, S., Takahashi, K., Yamasaki, M. and Yamada, Y. (1976). „The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus”. J. Biochem. (Tokyo). 80: 975—981. PMID 12156.
- ^ Tanaka, N., Takeuchi, M. and Ichishima, E. (1977). „Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity”. Biochim. Biophys. Acta. 485: 406—416. PMID 21699.
- ^ Ostoslavskaya, V.I., Kotlova, E.K., Stepanov, V.M., Rudenskaya, G.H., Baratova, L.A. and Belyanova, L.P. (1976). „Aspergillopepsin F-A carboxylic proteinase from Aspergillus foetidus”. Bioorg. Khim. 5: 595—603.
- ^ Panneerselvam, M. & Dhar, S.C. (1981). „Studies on the peptide bond specificity and the essential groups of an acid proteinase from Aspergillus fumigatus”. Ital. J. Biochem. 30: 207—216. PMID 7024192.
- ^ Ostoslavskaya, V.I., Revina, L.P., Kotlova, E.K., Surova, I.A., Levin, E.D., Timokhima, E.A. and Stepanov, V.M. (1986). „The primary structure of aspergillopepsin A, aspartic proteinase from Aspergillus awamori. IV. Amino acid sequence of the enzyme”. Bioorg. Khim. 12: 1030—1047.
- ^ Yagi, F., Fan, J., Tadera, K. and Kobayashi, A. (1986). „Purification and characterization of carboxyl proteinase from Aspergillus kawachii”. Agric. Biol. Chem. 50: 1029—1033.
- ^ Majima, E., Oda, K., Murao, S. and Ichishima, E. (1988). „Comparative study on the specificities of several fungal aspartic and acidic proteinases towards the tetradecapeptide of a renin substrate”. Agric. Biol. Chem. 52: 787—793.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Aspergillopepsin+I на US National Library of Medicine Medical Subject Headings (MeSH)
