Atrolizin B
| Atrolizin B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.41 | ||||||||
| CAS broj | 172306-48-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Atrolizin B (EC 3.4.24.41, Crotalus atrox metaloendopeptidaza b, hemoragijski toksin b, Ht-b) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu i Gly23-Phe u lancu insulina B; identično sa razlganjem lanca insulina B posredstvom atrolisina C. Ovaj enim takođe razlaže -Ser veze u glukagonu
Ovaj enzim je komponenta venuma zvečarke Crotalus atrox.
Reference[уреди | уреди извор]
- ^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.
- ^ Bjarnason, J.B., Hamilton, D. and Fox, J.W. (1988). „Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom”. Biol. Chem. Hoppe-Seyler. 369: 121—129. PMID 3060135.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Atrolysin+B на US National Library of Medicine Medical Subject Headings (MeSH)
