BMY-14802

Из Википедије, слободне енциклопедије
BMY-14802
BMY-14802 structure.png
IUPAC ime
1-(4-fluorophenyl)-4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]butan-1-ol
Identifikatori
CAS broj 105565-55-7 ДаY
ATC kod none
PubChem CID 108046
Hemijski podaci
Formula C18H22F2N4O
Molarna masa 348.389 g/mol
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BMY-14802 je lek sa antipsihotičkim dejstvom. On je antagonist sigma receptora, i agonist 5-HT1A receptora.[1][2][3][4]

Reference[уреди]

  1. Taylor DP, Eison MS, Moon SL, Schlemmer RF, Shukla UA, VanderMaelen CP, Yocca FD, Gallant DJ, Behling SH, Boissard CG (1993). „A role for sigma binding in the antipsychotic profile of BMY 14802?”. NIDA Research Monograph. 133: 125—57. PMID 8232511. 
  2. Vanecek SA, Essman WD, Taylor DP, Woods JH (1998). „Discriminative stimulus characteristics of BMY 14802 in the pigeon”. The Journal of Pharmacology and Experimental Therapeutics. 284 (1): 1—9. PMID 9435153. 
  3. Kitanaka J, Kitanaka N, Tatsuta T, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Morita Y, Takemura M (2009). „Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice”. Psychopharmacology. 203 (4): 781—92. doi:10.1007/s00213-008-1425-z. PMID 19052726. 
  4. Paquette MA, Foley K, Brudney EG, Meshul CK, Johnson SW, Berger SP (2009). „The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism”. Psychopharmacology. 204 (4): 743—54. doi:10.1007/s00213-009-1505-8. PMC 2845289слободно за читање. PMID 19283364. 

Spoljašnje veze[уреди]

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