CCL7

Из Википедије, слободне енциклопедије
Hemokin (C-C motiv) ligand 7
PDB prikaz baziran na 1bo0.
Dostupne strukture
1bo0, 1ncv
Identifikatori
Simboli CCL7; FIC; MARC; MCP-3; MCP3; MGC138463; MGC138465; NC28; SCYA7
Vanjski ID OMIM158106 MGI99512 HomoloGene4568 GeneCards: CCL7 Gene
Pregled RNK izražavanja
PBB GE CCL7 208075 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6354 20306
Ensembl ENSG00000108688 ENSMUSG00000035373
UniProt P80098 Q5SVU0
RefSeq (mRNA) NM_006273 NM_013654
RefSeq (protein) NP_006264 NP_038682
Lokacija (UCSC) Chr 17:
29.62 - 29.62 Mb
Chr 11:
81.86 - 81.86 Mb
PubMed pretraga [1] [2]

CCL7, hemokin (C-C motiv) ligand 7 je mali citokin. Ovaj hemokin se ranije zvao monocit-specifični hemokin 3 (MCP3). Pošto CCL7 poseduje dva susedna N-terminalna cisteinska ostatka u svom završnom obliku, on je klasifikovan u potfamiliju hemokina poznatih kao CC hemokini. CCL7 specifično privlači monocite, i reguliše makrofagne funkcije. Njega proizvode određene tumorske ćelijske linije i makrofage.[1] Ovaj hemokin je lociran na hromozomu 17 kod ljudi, u velikom klasteru koji sadrži mnoge druge CC hemokine[2]. On je srodan sa hemokinom CCL2 (koji se ranije zvao MCP1).[3]

Interakcije[уреди]

Za CCL7 je bilo pokazano da interaguje sa MMP2.[4]

Reference[уреди]

  1. Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). „Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines”. Biochem. Biophys. Res. Commun. 191 (2): 535—42. doi:10.1006/bbrc.1993.1251. PMID 8461011. 
  2. Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). „The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12”. Genomics. 21 (2): 403—8. doi:10.1006/geno.1994.1283. PMID 7916328. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  4. McQuibban, G A; Gong J H, Tam E M, McCulloch C A, Clark-Lewis I, Overall C M (2000). „Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3”. Science. UNITED STATES. 289 (5482): 1202—6. ISSN 0036-8075. PMID 10947989. 

Literatura[уреди]

  • Menten P, Wuyts A, Van Damme J (2002). „Monocyte chemotactic protein-3.”. Eur. Cytokine Netw. 12 (4): 554—60. PMID 11781181. 
  • Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). „Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.”. J. Exp. Med. 176 (1): 59—65. doi:10.1084/jem.176.1.59. PMC 2119277Слободан приступ. PMID 1613466. 
  • Ben-Baruch A; Xu L; Young PR; et al. (1995). „Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3.”. J. Biol. Chem. 270 (38): 22123—8. PMID 7545673. 
  • Opdenakker G; Fiten P; Nys G; et al. (1994). „The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.”. Genomics. 21 (2): 403—8. doi:10.1006/geno.1994.1283. PMID 7916328. 
  • Minty A; Chalon P; Guillemot JC; et al. (1993). „Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.”. Eur. Cytokine Netw. 4 (2): 99—110. PMID 8318676. 
  • Opdenakker G; Froyen G; Fiten P; et al. (1993). „Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.”. Biochem. Biophys. Res. Commun. 191 (2): 535—42. doi:10.1006/bbrc.1993.1251. PMID 8461011. 
  • Combadiere C; Ahuja SK; Van Damme J; et al. (1996). „Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.”. J. Biol. Chem. 270 (50): 29671—5. doi:10.1074/jbc.270.50.29671. PMID 8530354. 
  • Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). „Chemokine and chemokine receptor mRNA expression in human platelets.”. Cytokine. 7 (6): 479—82. doi:10.1006/cyto.1995.0065. PMID 8580362. 
  • Daugherty BL; Siciliano SJ; DeMartino JA; et al. (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor.”. J. Exp. Med. 183 (5): 2349—54. doi:10.1084/jem.183.5.2349. PMC 2192548Слободан приступ. PMID 8642344. 
  • Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD (1996). „Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.”. FEBS Lett. 395 (2-3): 277—82. doi:10.1016/0014-5793(96)01024-1. PMID 8898111. 
  • Meunier S; Bernassau JM; Guillemot JC; et al. (1997). „Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.”. Biochemistry. 36 (15): 4412—22. doi:10.1021/bi9627929. PMID 9109648. 
  • Polentarutti N; Introna M; Sozzani S; et al. (1997). „Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells.”. Eur. Cytokine Netw. 8 (3): 271—4. PMID 9346360. 
  • Bonini JA; Martin SK; Dralyuk F; et al. (1997). „Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.”. DNA Cell Biol. 16 (10): 1249—56. doi:10.1089/dna.1997.16.1249. PMID 9364936. 
  • Nibbs RJ; Wylie SM; Yang J; et al. (1998). „Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.”. J. Biol. Chem. 272 (51): 32078—83. doi:10.1074/jbc.272.51.32078. PMID 9405404. 
  • Wang JM; Ueda H; Howard OM; et al. (1998). „HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.”. J. Immunol. 161 (8): 4309—17. PMID 9780207. 
  • Albini A; Ferrini S; Benelli R; et al. (1998). „HIV-1 Tat protein mimicry of chemokines.”. Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13153—8. doi:10.1073/pnas.95.22.13153. PMC 23742Слободан приступ. PMID 9789057. 
  • Rabin RL; Park MK; Liao F; et al. (1999). „Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.”. J. Immunol. 162 (7): 3840—50. PMID 10201901. 
  • Wedemeyer J; Lorentz A; Göke M; et al. (1999). „Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa.”. Gut. 44 (5): 629—35. PMC 1727483Слободан приступ. PMID 10205198. 
  • Blanpain C; Migeotte I; Lee B; et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.”. Blood. 94 (6): 1899—905. PMID 10477718. 
  • Jordan NJ; Kolios G; Abbot SE; et al. (1999). „Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.”. J. Clin. Invest. 104 (8): 1061—9. doi:10.1172/JCI6685. PMC 408573Слободан приступ. PMID 10525044. 

Spoljašnje veze[уреди]