Defosfo-(reduktaza kinaza) kinaza

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Defosfo-(reduktaza kinaza) kinaza
Identifikatori
EC broj2.7.11.3
CAS broj72060-33-4
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Strukture PBPRCSB PDB PDBe PDBsum

Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3, AMP-activirana kinaza, AMP-activirana proteinska kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza (fosforilacija), reduktazna kinaza, reduktazna kinaza kinaza, STK30) je enzim sa sistematskim imenom ATP:defosfo-{(hidroksimetilglutaril-KoA reduktaza (NADPH)) kinaza} fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + defosfo-{[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza} ADP + {[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}

Ovaj enzim se aktivira AMP-om i specifičan je za svoj supstrat.

Reference[уреди]

  1. ^ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). „Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase”. Proc. Natl. Acad. Sci. USA. 76: 4375—4379. PMID 291971. 
  2. ^ Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268—1277. PMID 666819. 
  3. ^ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). „Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase”. J. Biol. Chem. 260: 1682—1687. PMID 3155737. 
  4. ^ Clarke, P.R. & Hardie, D.G. (1990). „Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver”. EMBO J. 9: 2439—2446. PMID 2369897. 
  5. ^ Sato, R., Goldstein, J.L. and Brown, M.S. (1993). „Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion”. Proc. Natl. Acad. Sci. USA. 90: 9261—9265. PMID 8415689. 

Literatura[уреди]

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