2-Metilcitrat sintaza
(преусмерено са EC 2.3.3.5)
| 2-Metilcitrat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.5 | ||||||||
| CAS broj | 57827-78-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Metilcitrat sintaza (EC 2.3.3.5, 2-metilcitrat oksaloacetatna lijaza, MCS, metilcitratna sintaza, metilcitratna sintetaza) je enzim sa sistematskim imenom propanoil-KoA:oksaloacetat C-propanoiltransferaza (tioestarska hidroliza, formiranje 1-karboksietila).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- propanoil-KoA + H2O + oksaloacetat (2R,3S)-2-hidroksibutan-1,2,3-trikarboksilat + KoA
Ovaj enzim deluje na acetil-KoA, propanoil-KoA, butanoil-KoA i pentanoil-KoA.
Reference[уреди | уреди извор]
- ^ Uchiyama, H. & Tabuchi, T. (1976). „Properties of methylcitrate synthase from Candida lipolytica”. Agric. Biol. Chem. 40: 1411—1418.
- ^ Textor, S., Wendisch, V.F., De Graaf, A.A., Muller, U., Linder, M.I., Linder, D. and Buckel, W. (1997). „Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria”. Arch. Microbiol. 168: 428—436. PMID 9325432.
- ^ Horswill, A.R. & Escalante-Semerena, J.C. (1999). „Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle”. J. Bacteriol. 181: 5615—5623. PMID 10482501.
- ^ van Rooyen, J.P., Mienie, L.J., Erasmus, E., De Wet, W.J., Ketting, D., Duran, M. and Wadman, S.K. (1994). „Identification of the stereoisomeric configurations of methylcitric acid produced by Si-citrate synthase and methylcitrate synthase using capillary gas chromatography-mass spectrometry”. J. Inherit. Metab. Dis. 17: 738—747. PMID 7707698.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 2-methylcitrate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
