Piroglutamilna peptidaza I
(преусмерено са EC 3.4.19.3)
| Piroglutamilna peptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.3 | ||||||||
| CAS broj | 9075-21-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Piroglutamilna peptidaza I (EC 3.4.19.3, 5-oksoprolilna peptidaza, piraza, piroglutamatna aminopeptidaza, piroglutamilna aminopeptidaza, L-piroglutamil peptidna hidrolaza, pirolidon-karboksilna peptidaza, pirolidon-karboksilatna peptidaza, pirolidonilna peptidaza, L-pirolidonkarboksilatna peptidaza, piroglutamidaza, pirolidonkarboksilol peptidaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalne piroglutamilne grupe sa polipeptida, pri čemu druga aminokiselina generalno nije Pro
Ovaj cisteinska peptidaza, je izolovana iz bakterija, biljki i životinja.
Reference[уреди | уреди извор]
- ^ Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K. (1984). „Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme”. Biochim. Biophys. Acta. 791: 117—122.
- ^ Awadé, A.C., Cleuziat, P., Gonzalès, T. and Robert-Baudouy, J. (1994). „Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins”. Proteins: Struct. Funct. Genet. 20: 34—51. PMID 7824521.
- ^ Patti, J.M., Schneider, A., Garza, N. and Boles, J.O. (1995). „Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus'”. Gene. 166: 95—99. PMID 8529900.
- ^ Le Saux, O., Gonzalès, T. and Robert-Baudouy, J. (1996). „Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase”. J. Bacteriol. 178: 3308—3313. PMID 8655512.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Pyroglutamyl-peptidase+I на US National Library of Medicine Medical Subject Headings (MeSH)
