Ehotiophat

Из Википедије, слободне енциклопедије
Ehotiophat
Echothiophate iodide.svg
Echothiophate-Molecule-3D-balls.png
Klinički podaci
Prodajno ime Echodide, Phospholine Iodide
Drugs.com Monografija
Način primene Oftalmički
Identifikatori
CAS broj 6736-03-4 ДаY
ATC kod None
PubChem CID 10547
DrugBank DB01057 ДаY
ChemSpider 10107 ДаY
ChEBI CHEBI:4753 ДаY
ChEMBL CHEMBL1201341 ДаY
Hemijski podaci
Formula C9H23NO3PS
Molarna masa 256,323
Fizički podaci
Tačka topljenja 138 °C (280 °F)

Ehotiophat je organsko jedinjenje, koje sadrži 9 atoma ugljenika i ima molekulsku masu od 256,323 Da.[1][2][3][4]

Osobine[уреди]

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 0
Broj rotacionih veza 8
Particioni koeficijent[5] (ALogP) -0,1
Rastvorljivost[6] (logS, log(mol/L)) -2,5
Polarna površina[7] (PSA, Å2) 70,6

Reference[уреди]

  1. Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. PMID 20673046 20673046
  2. Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. PMID 7166393
  3. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. 
  4. David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research 36 (Database issue): D901—6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. 
  5. Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762—3772. doi:10.1021/jp980230o. 
  6. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. doi:10.1021/ci000392t. PMID 11749573. 
  7. Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. doi:10.1021/jm000942e. PMID 11020286. 

Literatura[уреди]

Spoljašnje veze[уреди]