Receptor 3 fibroblastnog faktora rasta

FGFR3
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	1RY7, 2LZL, 4K33
Identifikatori
Alijasi	FGFR3
Spoljašnji ID	OMIM: 134934 MGI: 95524 HomoloGene: 55437 GeneCards: FGFR3
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	33,894,412 bp
Obrazac RNK izražavanja
	; ;
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • GO:0001948, GO:0016582 везивање за протеине плазме; • transmembrane receptor protein tyrosine kinase activity; • fibroblast growth factor binding; • fibroblast growth factor-activated receptor activity; • ATP binding; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 1-phosphatidylinositol-3-kinase activity; • identical protein binding; • Receptor tirozinska kinaza; • transmembrane signaling receptor activity;
Cellular component	• цитоплазма; • саставни део мембране; • Голџијев апарат; • мембрана; • focal adhesion; • ћелијска мембрана; • integral component of plasma membrane; • transport vesicle; • ванћелијска област; • површина ћелије; • ендоплазматични ретикулум; • GO:0016023 cytoplasmic vesicle; • једро; • receptor complex;
Biological process	• bone mineralization; • chondrocyte differentiation; • Fosforilacija; • negative regulation of developmental growth; • cell-cell signaling; • bone morphogenesis; • endochondral ossification; • bone maturation; • fibroblast growth factor receptor apoptotic signaling pathway; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of phospholipase activity; • fibroblast growth factor receptor signaling pathway; • protein phosphorylation; • chondrocyte proliferation; • positive regulation of cell population proliferation; • positive regulation of ERK1 and ERK2 cascade; • protein autophosphorylation; • peptidyl-tyrosine phosphorylation; • endochondral bone growth; • positive regulation of MAPK cascade; • GO:0097285 апоптоза; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • positive regulation of tyrosine phosphorylation of STAT protein; • skeletal system development; • positive regulation of protein kinase B signaling; • negative regulation of signal transduction; • диференцијација; • негативно регулисање апоптотичког процеса; • transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Ortolozi
	2261
	14184
	ENSG00000068078
	ENSMUSG00000054252
	P22607
	Q61851
	NM_000142; NM_001163213; NM_022965; NM_001354809; NM_001354810
NM_001163215; NM_001163216; NM_001163217; NM_001205270; NM_008010;
	NM_001359036; NM_001359037
	NP_000133; NP_001156685; NP_075254; NP_001341738; NP_001341739
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor 3 fibroblastnog faktora rasta je protein koji je kod ljudi kodiran FGFR3 genom.^[4] FGFR3 se takođe obeležava sa CD333 (klaster diferencijacije 333).

Struktura i funkcija[уреди | уреди извор]

Protein kodiran ovim genom je član familije receptora fibroblastnih faktora rasta (FGFR) među kojima je aminokiselinska sekvenca visoko konzervirana tokom evolucije. Članovi FGFR familije se međusobno razlikuju po nihovom afinitetu za ligande i tkivnoj distribuciji. Reprezentativni protein pune dužine se sastoji od ekstracelularnog regiona, sastavljenog od tri imunoglobulinu slična domena, jednog hidrofobnog jednoprolaznog membranskog segmenta i citoplazmatičnog tirozinskog kinaznog domena. Ekstracelularna porcija proteina interaguje sa fibroblastnim faktorima rasta, čime se pokreće signalna kaslada koja utiče na mitogenezu i diferencijaciju. Ovaj član familije se vezuje za kisele i bazne fibroblastne faktore rasta. Mutacije ovog gena dovode do kraniosinostoze i višestrukih tipova skeletalnih displazija. Alternativno splajsovanje se javlja i dodatne varijante su opisane, inključujući one koje koriste alternativni ekson 8 umesto 9, ali one nisu dovoljno ispitane.^[5]

Interakcije[уреди | уреди извор]

Receptor 3 fibroblastnog faktora rasta formira interakcije sa FGF1^[6]^[7] i FGF9.^[6]^[7]

Vidi još[уреди | уреди извор]

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000054252 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Keegan K, Johnson DE, Williams LT, Hayman MJ (1991). „Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3”. Proc Natl Acad Sci U S A. 88 (4): 1095—9. PMC 50963 . PMID 1847508. doi:10.1073/pnas.88.4.1095.
^ „Entrez Gene: FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)”.
^ ^а ^б Santos-Ocampo, S; Colvin J S; Chellaiah A; Ornitz D M (1996). „Expression and biological activity of mouse fibroblast growth factor-9”. J. Biol. Chem. UNITED STATES. 271 (3): 1726—31. ISSN 0021-9258. PMID 8576175. doi:10.1074/jbc.271.3.1726.
^ ^а ^б Chellaiah, A; Yuan W; Chellaiah M; Ornitz D M (1999). „Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity”. J. Biol. Chem. UNITED STATES. 274 (49): 34785—94. ISSN 0021-9258. PMID 10574949. doi:10.1074/jbc.274.49.34785.

Literatura[уреди | уреди извор]

{{PBB_Further_reading | citations =

Schweitzer DN, Graham JM, Lachman RS, Jabs EW, Okajima K, Przylepa KA, Shanske A, Chen K, Neidich JA, Wilcox WR (2001). „Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3”. American Journal of Medical Genetics. 98 (1): 75—91. PMID 11426459. doi:10.1002/1096-8628(20010101)98:1<75::AID-AJMG1010>3.0.CO;2-6.
Horton WA, Lunstrum GP (2002). „Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism”. Reviews in Endocrine & Metabolic Disorders. 3 (4): 381—5. PMID 12424440.
Bonaventure J, Silve C (2005). „[Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways]”. Médecine Sciences. 21 (11): 954—61. PMID 16274647. doi:10.1051/medsci/20052111954.
Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM, Real FX (2007). „Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors”. The Journal of Investigative Dermatology. 127 (7): 1664—6. PMID 17255960. doi:10.1038/sj.jid.5700705.
Olsen SK, Ibrahimi OA, Raucci A, Zhang F, Eliseenkova AV, Yayon A, Basilico C, Linhardt RJ, Schlessinger J, Mohammadi M (2004). „Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity”. Proceedings of the National Academy of Sciences of the United States of America. 101 (4): 935—40. PMC 327120 . PMID 14732692. doi:10.1073/pnas.0307287101.

Spoljašnje veze[уреди | уреди извор]

GeneReviews/NIH/NCBI/UW entry on FGFR-Related Craniosynostosis Syndromes
GeneReviews/NIH/NCBI/UW entry on Muenke Syndrome
GeneReviews/NIH/NCBI/UW entry on Achondroplasia
GeneReviews/NIH/NCBI/UW entry on Hypochondroplasia
GeneReviews/NIH/NCBI/UW entry on Thanatophoric Dysplasia
FGFR3+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000054252 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1847508-4] Keegan K, Johnson DE, Williams LT, Hayman MJ (1991). „Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3”. Proc Natl Acad Sci U S A. 88 (4): 1095—9. PMC 50963 . PMID 1847508. doi:10.1073/pnas.88.4.1095.

[5] „Entrez Gene: FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)”.

[pmid8576175-6] а ^б Santos-Ocampo, S; Colvin J S; Chellaiah A; Ornitz D M (1996). „Expression and biological activity of mouse fibroblast growth factor-9”. J. Biol. Chem. UNITED STATES. 271 (3): 1726—31. ISSN 0021-9258. PMID 8576175. doi:10.1074/jbc.271.3.1726.

[pmid10574949-7] а ^б Chellaiah, A; Yuan W; Chellaiah M; Ornitz D M (1999). „Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity”. J. Biol. Chem. UNITED STATES. 274 (49): 34785—94. ISSN 0021-9258. PMID 10574949. doi:10.1074/jbc.274.49.34785.

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п р у Receptori: Receptori faktora rasta
Nervni faktori rasta	niski afinitet/p75 – visok afinitet Trk (TrkA, TrkB, TrkC) – Cilijarni neurotrofni faktor
Somatomedin	Insulinu-sličan faktor rasta 1 – Insulinu-sličan faktor rasta 2
CSF	Stem ćelijski faktor – Eritropoietin
TGF put	TGF-beta (1, 2) – Aktivin (1, 2) – Bone morfogenetski protein (1, 2)
Drugi	Hepatocitni faktor rasta – ErbB/Epidermalni faktor rasta – Fibroblast faktor rasta (1, 2, 3, 4) – Trombocit-izvedeni faktor rasta (A, B) – VEGF (1, 2, 3)
vidi isto Faktori rasta

п р у Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350