Farmakokinetika

Из Википедије, слободне енциклопедије

Farmakokinetika, skraćeno PK, (od starogrčkog pharmakon "lek" i kinetikos "vezano za kretanje") je grana farmakologije koja se bavi izučavanjem promena supstanci doziranih u žive organizme. Reč farmakokinetika prvi put uveo je Friedrich Hartmut Dost 1953. godine u Nemačkoj i disciplinu definisao kao nauku kvantitativne analize odnosa između organizma i leka. Supstance od interesa su farmaceutski agensi, hormoni, nutrijenti, i toksini. Ona pokužava da otkrije sudbinu leka od momenta njegovog unosa do tačke u kojoj je kompletno eliminisan iz tela.

Farmakokinetika se može jednostavno definisati kao to što telo radi leku, dok je farmakodinamika usredsređena na to što lek radi telu.[1]

Grafikon koji demonstrira Mihaelis-Menteninov kinetčki model odnosa između enzima i supstrata

Farmakokinetika opisuje kako telo deluje na specifični lek nakon doziranja putem mehanizama apsorpcije i distribucije, kao i hemijske promene supstane u telu (e.g. posredstvom metaboličkih enzima kao što su enzimi citohrom P450 ili glukuronoziltransferaza), i efekte i puteve izlučivanja metabolita leka.[2] Farmakokinetička svojstva leka mogu da budu uslovljena faktorima poput mesta administriranja i doze leka. Ti faktori mogu da utiču na brzinu apsorpcije.[3] Farmakokinetika se često studira zajedno sa farmakodinamikom.

Vidi još[уреди]

Reference[уреди]

  1. Benet LZ (1984). „Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug Metabolism”. Ур.: Horning MG, Mitchell J. Drug metabolism and drug toxicity. New York: Raven Press. ISBN 0-89004-997-1. 
  2. Pharmacokinetics. (2006). In Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Retrieved December 11, 2008, from http://www.credoreference.com/entry/6686418
  3. Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5. 

Literatura[уреди]

  • Benet LZ (1984). „Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug Metabolism”. Ур.: Horning MG, Mitchell J. Drug metabolism and drug toxicity. New York: Raven Press. ISBN 0-89004-997-1. 
  • Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5. 
  • Alberts et al., Introducción a la Biología Celular, pág. 375-376, 2ª edición, Ed. Médica Panamericana
  • Alberts et al., Biología Molecular de la célula, pág. 595, 4ª edición, Ed. Omega
  • Armijo JA. 2003. Farmacocinética: Absorción, Distribución y Eliminación de los Fármacos. En: Flórez J, Armijo JA, Mediavilla A, Farmacología Humana, 4ta edición. Masson. Barcelona. pp: 51-79.
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  • Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5.
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  • Malcolm Rowland, Thomas N. Tozer. "Farmacocinética clínica: Conceptos y Aplicaciones"
  • Pharmacokinetics. (2006). En Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Disponible en [2] Última visita 11, diciembre de 2008,
  • Sheehan D, Meade G, Foley V, Dowd C (2001). "Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily". Biochem J 360 (Pt 1): 1-16. PMID 11695986.
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  • Sheiner, L.B.; Rosenberg, B., Marathe, V.V. "Estimation of Population Characteristics of Pharmacokinetic Parameters from Routine Clinical Data". J. Pharmacokin. Biopharm. 5: 445–79. 1.997 doi:10.1007/BF01061728.
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  • Singh SS., Preclinical pharmacokinetics: an approach towards safer and efficacious drugs, Curr Drug Metab. 2006 Feb;7(2):165-82.
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  • Tetko IV, Bruneau P, Mewes HW, Rohrer DC, Poda GI., Can we estimate the accuracy of ADME-Tox predictions?, Drug Discov Today. 2006 Aug;11(15-16):700-7, pre-print.
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  • Vertuani S, Angusti A, Manfredini S (2004). "The antioxidants and pro-antioxidants network: an overview". Curr Pharm Des 10 (14): 1677-94. PMID 15134565.

Spoljašnje veze[уреди]