Fenelzin
Изглед
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Klinički podaci | |
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Prodajno ime | Beta-phenylethylhydrazine, Fenelzina [INN-Spanish], Fenelzyna, Fenelzyne |
Drugs.com | Monografija |
Način primene | Oralno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 1,2-11,6 h |
Identifikatori | |
CAS broj | 51-71-8 ![]() |
ATC kod | N06AF03 (WHO) |
PubChem | CID 3675 |
DrugBank | DB00780 ![]() |
ChemSpider | 3547 ![]() |
KEGG | C07430 ![]() |
ChEMBL | CHEMBL1089 ![]() |
Hemijski podaci | |
Formula | C8H12N2 |
Molarna masa | 136,194 |
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Fizički podaci | |
Tačka ključanja | 74 °C (165 °F) |
Fenelzin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 136,194 Da.[1][2][3][4]
Osobine
[уреди | уреди извор]Osobina | Vrednost |
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Broj akceptora vodonika | 2 |
Broj donora vodonika | 2 |
Broj rotacionih veza | 3 |
Particioni koeficijent[5] (ALogP) | 0,9 |
Rastvorljivost[6] (logS, log(mol/L)) | -1,9 |
Polarna površina[7] (PSA, Å2) | 38,0 |
Reference
[уреди | уреди извор]- ^ Nolen WA: [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression] Ned Tijdschr Geneeskd. Nolen, W. A. (октобар 2003). „Classical monoamine oxidase inhibitor: Not registered for, but still a place in the treatment of depression”. Nederlands Tijdschrift voor Geneeskunde. 147 (40): 1940—3. PMID 14574774.
- ^ Sowa BN, Holt A, Todd KG, Baker GB: Monoamine oxidase inhibitors, their structural analogues, and neuroprotection. Indian J Exp Biol. 2004 Sep;Sowa, B. N.; Holt, A.; Todd, K. G.; Baker, G. B. (2004). „Monoamine oxidase inhibitors, their structural analogues, and neuroprotection”. Indian Journal of Experimental Biology. 42 (9): 851—7. PMID 15462176.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. Текст „noedit” игнорисан (помоћ)
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. Текст „noedit” игнорисан (помоћ)
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Текст „noedit” игнорисан (помоћ)
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Текст „noedit” игнорисан (помоћ)
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]![]() | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |