С Википедије, слободне енциклопедије
Fluorouracil Prodajno ime Adrucil, Arumel, Carac, Carzonal Drugs.com Monografija Način primene Topikalno, intravenozno Poluvreme eliminacije 10-20 minuta Izlučivanje Renalno
CAS broj 51-21-8 Y ATC kod L01BC02 (WHO PubChem CID 3385 DrugBank DB00544 Y ChemSpider 3268 Y KEGG C07649 Y ChEBI CHEBI:46345 Y ChEMBL CHEMBL185 Y Formula C 4 H 3 F N 2 O 2 Molarna masa 130,077
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
Y Key:GHASVSINZRGABV-UHFFFAOYSA-N
Y
Tačka topljenja
Fluorouracil je organsko jedinjenje , koje sadrži 4 atoma ugljenika i ima molekulsku masu od 130,077 Da .[1] [2] [3] [4]
^ Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. PMID 12724731
^ Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. PMID 15032669
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs” . Nucleic Acids Res . 39 (Database issue): D1035—41. PMC 3013709 PMID 21059682 . doi :10.1093/nar/gkq1126 . ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets” . Nucleic acids research . 36 (Database issue): D901—6. PMC 2238889 PMID 18048412 . doi :10.1093/nar/gkm958 . ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods” . J. Phys. Chem. A . 102 : 3762—3772. doi :10.1021/jp980230o . ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices” . Chem Inf. Comput. Sci . 41 : 1488—1493. PMID 11749573 . doi :10.1021/ci000392t . ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties” . J. Med. Chem . 43 : 3714—3717. PMID 11020286 . doi :10.1021/jm000942e .
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. PMID 21059682. doi:10.1093/nar/gkq1126.
