Fosducin

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Fosducin
PDB prikaz baziran na 2trc.
Dostupne strukture
2trc
Identifikatori
Simboli PDC; PhLP; MEKA; PHD; PhLOP
Vanjski ID OMIM171490 MGI98090 HomoloGene1950 GeneCards: PDC Gene
Pregled RNK izražavanja
PBB GE PDC 211496 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5132 20028
Ensembl ENSG00000116703 ENSMUSG00000006007
UniProt P20941 Q9QW08
RefSeq (mRNA) NM_002597 NM_024458
RefSeq (protein) NP_002588 NP_077778
Lokacija (UCSC) Chr 1:
184.68 - 184.7 Mb
Chr 1:
152.08 - 152.1 Mb
PubMed pretraga [1] [2]

Fosducin, takođe poznat kao PDC, je ljudski protein i gen.[1] On pripada fosducin familiji of proteina.

Ovaj gen kodira fosfoprotein, koji je lociran u vanjski i unutarnji segmentima štapićastih ćelija mrežnjače. Ovaj protein može da sudeluje u regulaciji vizuelne fototransdukcije ili u integraciji fotoreceptorskog metabolizama. On modulira fototransdukcionu kaskadu putem interakcije sa beta i gama podjedinicama retinalnog G-proteina transducina. Vezivanjem za te dve podjedinice transducin će ostati vezan za alfa podjedinicu duže. To produžava trajanje vizuelne pobude.

Ovaj gen je potencijalni kandidat za retinitis pigmentosa i Ušerov sindrom tipa II. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su bile identifikovane.[1]

Reference[уреди]

Literatura[уреди]

  • Abe T, Nakabayashi H, Tamada H; et al. (1990). „Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.”. Gene 91 (2): 209—15. doi:10.1016/0378-1119(90)90090-E. PMID 2210381. 
  • Watanabe Y, Kawasaki K, Miki N, Kuo CH (1990). „Isolation and analysis of the human MEKA gene encoding a retina-specific protein.”. Biochem. Biophys. Res. Commun. 170 (2): 951—6. doi:10.1016/0006-291X(90)92183-Z. PMID 2383274. 
  • Lee RH, Brown BM, Lolley RN (1990). „Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.”. J. Biol. Chem. 265 (26): 15860—6. PMID 2394752. 
  • Hawes BE, Touhara K, Kurose H; et al. (1994). „Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.”. J. Biol. Chem. 269 (47): 29825—30. PMID 7961975. 
  • Abe T, Kikuchi T, Shinohara T (1994). „The sequence of the human phosducin gene (PDC) and its 5'-flanking region.”. Genomics 19 (2): 369—72. doi:10.1006/geno.1994.1072. PMID 8188267. 
  • Sparkes RS, Lee RH, Shinohara T; et al. (1994). „Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization.”. Genomics 18 (2): 426—8. doi:10.1006/geno.1993.1490. PMID 8288249. 
  • Ding C, Li X, Griffin CA; et al. (1994). „The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1.”. Genomics 18 (2): 457—9. doi:10.1006/geno.1993.1501. PMID 8288259. 
  • Boekhoff I, Touhara K, Danner S; et al. (1997). „Phosducin, potential role in modulation of olfactory signaling.”. J. Biol. Chem. 272 (7): 4606—12. doi:10.1074/jbc.272.7.4606. PMID 9020189. 
  • Barhite S, Thibault C, Miles MF (1998). „Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1.”. Biochim. Biophys. Acta 1402 (1): 95—101. doi:10.1016/S0167-4889(97)00141-9. PMID 9551090. 
  • Zhu X, Craft CM (1998). „Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1.”. Mol. Vis. 4: 13. PMID 9701609. 
  • Craft CM, Xu J, Slepak VZ; et al. (1998). „PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins.”. Biochemistry 37 (45): 15758—72. doi:10.1021/bi980921a. PMID 9843381. 
  • Carpten JD, Makalowska I, Robbins CM; et al. (2000). „A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.”. Genomics 64 (1): 1—14. doi:10.1006/geno.1999.6051. PMID 10708513. 
  • Zhu X, Craft CM (2000). „The carboxyl terminal domain of phosducin functions as a transcriptional activator.”. Biochem. Biophys. Res. Commun. 270 (2): 504—9. doi:10.1006/bbrc.2000.2414. PMID 10753654. 
  • Zhu X, Craft CM (2000). „Modulation of CRX transactivation activity by phosducin isoforms.”. Mol. Cell. Biol. 20 (14): 5216—26. doi:10.1128/MCB.20.14.5216-5226.2000. PMC 85970. PMID 10866677. 
  • Ruiz-Gómez A, Humrich J, Murga C; et al. (2000). „Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.”. J. Biol. Chem. 275 (38): 29724—30. doi:10.1074/jbc.M001864200. PMID 10884381. 
  • Nakano K, Chen J, Tarr GE; et al. (2001). „Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.”. Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4693—8. doi:10.1073/pnas.071067198. PMC 31896. PMID 11287646. 
  • Thulin CD, Savage JR, McLaughlin JN; et al. (2001). „Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.”. J. Biol. Chem. 276 (26): 23805—15. doi:10.1074/jbc.M101482200. PMID 11331285. 
  • Wistow G, Bernstein SL, Wyatt MK; et al. (2002). „Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.”. Mol. Vis. 8: 196—204. PMID 12107411. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Margulis A, Dang L, Pulukuri S; et al. (2002). „Presence of phosducin in the nuclei of bovine retinal cells.”. Mol. Vis. 8: 477—82. PMID 12500174. 

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