GABA transporter tip 1

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Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
Simboli SLC6A1; GABATHG; GABATR; GAT1
Vanjski ID OMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
Pregled RNK izražavanja
PBB GE SLC6A1 205152 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042.3 NM_178703.4
RefSeq (protein) NP_003033.3 NP_848818.1
Lokacija (UCSC) Chr 3:
11.03 - 11.08 Mb
Chr 6:
114.28 - 114.32 Mb
PubMed pretraga [1] [2]

GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.[1][2]

Funkcija[уреди]

GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.[3]

Interakcije[уреди]

SLC6A1 formira interakcije sa STX1A.[4][5][6]

Reference[уреди]

  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25”. Genomics. 29 (1): 302—4. PMID 8530094. doi:10.1006/geno.1995.1253. 
  2. ^ „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1”. 
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity”. Pharmacogenet. Genomics. 19 (1): 53—65. PMID 19077666. doi:10.1097/FPC.0b013e328318b21a. 
  4. ^ Beckman, M L; Bernstein EM; Quick M W (1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A”. J. Neurosci. UNITED STATES. 18 (16): 6103—12. ISSN 0270-6474. PMID 9698305. 
  5. ^ Quick, Michael W (2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner”. Proc. Natl. Acad. Sci. U.S.A. United States. 99 (8): 5686—91. ISSN 0027-8424. PMC 122832Слободан приступ. PMID 11960023. doi:10.1073/pnas.082712899. 
  6. ^ Deken, S L; Beckman M L; Boos L; Quick M W (2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A”. Nat. Neurosci. UNITED STATES. 3 (10): 998—1003. ISSN 1097-6256. PMID 11017172. doi:10.1038/79939. 

Literatura[уреди]

  • Nelson H, Mandiyan S, Nelson N (1990). „Cloning of the human brain GABA transporter.”. FEBS Lett. 269 (1): 181—4. PMID 2387399. doi:10.1016/0014-5793(90)81149-I. 
  • Bennett ER, Kanner BI (1997). „The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.”. J. Biol. Chem. 272 (2): 1203—10. PMID 8995422. doi:10.1074/jbc.272.2.1203. 
  • Bismuth Y, Kavanaugh MP, Kanner BI (1997). „Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.”. J. Biol. Chem. 272 (26): 16096—102. PMID 9195904. doi:10.1074/jbc.272.26.16096. 
  • DeFelipe J, González-Albo MC (1998). „Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.”. Neuroreport. 9 (3): 467—70. PMID 9512391. doi:10.1097/00001756-199802160-00020. 
  • Conti F; Melone M; De Biasi S; et al. (1998). „Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.”. J. Comp. Neurol. 396 (1): 51—63. PMID 9623887. doi:10.1002/(SICI)1096-9861(19980622)396:1<51::AID-CNE5>3.0.CO;2-H. 
  • Beckman ML, Bernstein EM, Quick MW (1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.”. J. Neurosci. 18 (16): 6103—12. PMID 9698305. 
  • Augood SJ; Waldvogel HJ; Münkle MC; et al. (1999). „Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.”. Neuroscience. 88 (2): 521—34. PMID 10197772. doi:10.1016/S0306-4522(98)00226-7. 
  • Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). „A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.”. J. Neurocytol. 27 (10): 719—30. PMID 10640187. doi:10.1023/A:1006946717065. 
  • Deken SL, Beckman ML, Boos L, Quick MW (2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.”. Nat. Neurosci. 3 (10): 998—1003. PMID 11017172. doi:10.1038/79939. 
  • Whitworth TL, Quick MW (2001). „Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.”. J. Biol. Chem. 276 (46): 42932—7. PMID 11555659. doi:10.1074/jbc.M107638200. 
  • Hachiya Y, Takashima S (2002). „Development of GABAergic neurons and their transporter in human temporal cortex.”. Pediatr. Neurol. 25 (5): 390—6. PMID 11744314. doi:10.1016/S0887-8994(01)00348-4. 
  • Quick MW (2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.”. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686—91. PMC 122832Слободан приступ. PMID 11960023. doi:10.1073/pnas.082712899. 
  • Kanner BI (2003). „Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.”. J. Biol. Chem. 278 (6): 3705—12. PMID 12446715. doi:10.1074/jbc.M210525200. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Zomot E, Kanner BI (2003). „The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.”. J. Biol. Chem. 278 (44): 42950—8. PMID 12925537. doi:10.1074/jbc.M209307200. 
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285. 
  • Zhou Y, Bennett ER, Kanner BI (2004). „The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.”. J. Biol. Chem. 279 (14): 13800—8. PMID 14744863. doi:10.1074/jbc.M311579200. 
  • Hu JH; Ma YH; Jiang J; et al. (2004). „Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).”. Neuroreport. 15 (1): 9—12. PMID 15106822. doi:10.1097/00001756-200401190-00003. 
  • Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). „Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.”. J. Biol. Chem. 279 (53): 55728—36. PMID 15496410. doi:10.1074/jbc.M409449200. 

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