GNAI2

Из Википедије, слободне енциклопедије
Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 2
Identifikatori
Simboli GNAI2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Vanjski ID OMIM139360 MGI95772 HomoloGene55539 GeneCards: GNAI2 Gene
Pregled RNK izražavanja
PBB GE GNAI2 201040 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2771 14678
Ensembl ENSG00000114353 n/a
UniProt P04899 n/a
RefSeq (mRNA) NM_002070 XM_980919
RefSeq (protein) NP_002061 XP_986013
Lokacija (UCSC) Chr 3:
50.24 - 50.27 Mb
n/a
PubMed pretraga [1] [2]

GNAI2, Guanin nukleotid-vezujući protein G(i), alfa-2 podjedinica, je protein koji je kod ljudi kodiran GNAI2 genom.[1][2][3]


Interakcije[уреди]

Za GNAI2 je bilo pokazano da formira interakcije sa GPSM2,[4][5] RIC8A,[6] Interleukin 8 receptor, alpha,[7][8] EYA2,[9] RGS5[10][11] i MDFI.[12]

Reference[уреди]

  1. Didsbury JR, Ho YS, Snyderman R (1987). „Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA”. FEBS Lett. 211 (2): 160—4. PMID 3100330. doi:10.1016/0014-5793(87)81428-X. 
  2. Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (1992). „Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13”. Genomics. 12 (1): 125—9. PMID 1733849. doi:10.1016/0888-7543(92)90414-N. 
  3. „Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2”. 
  4. Marty, Caroline; Browning Darren D; Ye Richard D (2003). „Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras”. Mol. Cell. Biol. United States. 23 (11): 3847—58. ISSN 0270-7306. PMC 155206Слободан приступ. PMID 12748287. doi:10.1128/MCB.23.11.3847-3858.2003. 
  5. Mochizuki, N; Cho G; et al. (1996). „Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2”. Gene. NETHERLANDS. 181 (1-2): 39—43. ISSN 0378-1119. PMID 8973305. doi:10.1016/S0378-1119(96)00456-8. 
  6. Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
  7. Damaj, B B; McColl S R; et al. (1996). „Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops”. FASEB J. UNITED STATES. 10 (12): 1426—34. ISSN 0892-6638. PMID 8903513. 
  8. Damaj, B B; McColl S R; et al. (1996). „Physical association of Gi2alpha with interleukin-8 receptors”. J. Biol. Chem. UNITED STATES. 271 (22): 12783—9. ISSN 0021-9258. PMID 8662698. doi:10.1074/jbc.271.22.12783. 
  9. Fan, X; Brass L F; et al. (2000). „The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins”. J. Biol. Chem. UNITED STATES. 275 (41): 32129—34. ISSN 0021-9258. PMID 10906137. doi:10.1074/jbc.M004577200. 
  10. Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  11. Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0. 
  12. Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209. 

Literatura[уреди]