GNAI3

Из Википедије, слободне енциклопедије
Иди на навигацију Иди на претрагу
Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 3
PDB prikaz baziran na 1agr.
Dostupne strukture
1agr, 1as0, 1as2, 1as3, 1bh2, 1bof, 1cip, 1gdd, 1gfi, 1gg2, 1gia, 1gil, 1git, 1gp2, 1kjy, 1svk, 1svs, 1y3a, 2g83, 2gtp, 2hlb, 2ihb, 2ik8, 2ode
Identifikatori
Simboli GNAI3; 87U6; FLJ26559
Vanjski ID OMIM139370 MGI95773 HomoloGene55975 GeneCards: GNAI3 Gene
Pregled RNK izražavanja
PBB GE GNAI3 201180 s at tn.png
PBB GE GNAI3 201179 s at tn.png
PBB GE GNAI3 201181 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2773 14679
Ensembl ENSG00000065135 ENSMUSG00000000001
UniProt P08754 Q3TJH1
RefSeq (mRNA) NM_006496 NM_010306
RefSeq (protein) NP_006487 NP_034436
Lokacija (UCSC) Chr 1:
109.89 - 109.94 Mb
Chr 3:
108.24 - 108.27 Mb
PubMed pretraga [1] [2]

GNAI3, Guanin nukleotid-vezujući protein G(i), alfa-3 podjedinica, je protein koji je kod ljudi kodiran GNAI3 genom.Didsbury JR, Snyderman R (1987). „Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families”. FEBS Lett. 219 (1): 259—63. PMID 3109953. doi:10.1016/0014-5793(87)81228-0. </ref>[1]


Interakcije[уреди]

Za GNAI3 je bilo pokazano da ostvaruje interakcije sa RGS14,[2] RIC8A,[3] RGS18,[4][5] S1PR1,[6] RGS12,[2] RGS16,[7][8] RGS19,[9][10][11] RGS10[12] i RGS5.[7][13]

Reference[уреди]

  1. ^ „Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3”. 
  2. 2,0 2,1 Kimple, R J; De Vries L; et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. United States. 276 (31): 29275—81. ISSN 0021-9258. PMID 11387333. doi:10.1074/jbc.M103208200. 
  3. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
  4. ^ Yowe, D; Weich N; et al. (2001). „RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. Biochem. J. England. 359 (Pt 1): 109—18. ISSN 0264-6021. PMC 1222126Слободан приступ. PMID 11563974. doi:10.1042/0264-6021:3590109. 
  5. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (2002). „Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cell. Signal. England. 14 (7): 595—606. ISSN 0898-6568. PMID 11955952. doi:10.1016/S0898-6568(02)00012-8. 
  6. ^ Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
  7. 7,0 7,1 Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  8. ^ Beadling, C; Druey K M; et al. (1999). „Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes”. J. Immunol. UNITED STATES. 162 (5): 2677—82. ISSN 0022-1767. PMID 10072511. 
  9. ^ De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC 26381Слободан приступ. PMID 8986788. doi:10.1073/pnas.93.26.15203. 
  10. ^ Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718. 
  11. ^ De Vries, L; Mousli M; et al. (1995). „GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 92 (25): 11916—20. ISSN 0027-8424. PMC 40514Слободан приступ. PMID 8524874. doi:10.1073/pnas.92.25.11916. 
  12. ^ Hunt, T W; Fields T A; et al. (1996). „RGS10 is a selective activator of G alpha i GTPase activity”. Nature. ENGLAND. 383 (6596): 175—7. ISSN 0028-0836. PMID 8774883. doi:10.1038/383175a0. 
  13. ^ Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0. 

Literatura[уреди]

Vidi još[уреди]