HTATIP

Из Википедије, слободне енциклопедије
HIV-1 Tat interagujući protein, 60 kDa
PDB prikaz baziran na 2ou2.
Dostupne strukture
2ou2
Identifikatori
Simboli HTATIP; ESA1; HTATIP1; PLIP; TIP; TIP60; cPLA2
Vanjski ID OMIM601409 MGI1932051 HomoloGene4657 GeneCards: HTATIP Gene
Pregled RNK izražavanja
PBB GE HTATIP 206689 x at tn.png
PBB GE HTATIP 209192 x at tn.png
PBB GE HTATIP 214258 x at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 10524 81601
Ensembl ENSG00000172977 ENSMUSG00000024926
UniProt Q92993 Q3UJQ1
RefSeq (mRNA) NM_006388 NM_178637
RefSeq (protein) NP_006379 NP_848752
Lokacija (UCSC) Chr 11:
65.24 - 65.24 Mb
Chr 19:
5.6 - 5.61 Mb
PubMed pretraga [1] [2]

HTATIP, histonska acetiltransferaza KAT5, je enzim koji je kod čoveka kodiran KAT5 genom.[1][2]

Protein kodiran ovim genom pripada MYST familiji histonskih acetil transferaza (HAT). On je bio originalno izolovan kao HIV-1 TAT-interaktivni protein. HAT proteini učestvuju u regulaciji hromatinskog remodelovanja, transkripciji i drugim nuklearnim procesima putem acetilacije histona i nehistonskih proteina. Ovaj protein je histonska acetilaza koja učestvuje u DNK popravci i apoptozi, i za nju se smatra da ima ulogu u prenosu signala. Alternativno splajsovanje ovog gena rezultuje u višestrukim transkriptnim varijantama.[2]

Interakcije[уреди]

Za HTATIP je bilo pokazano da interaguje sa HDAC7A,[3] FANCD2,[4] CREB1,[5] ETV6,[6] Mdm2,[7] Myc,[8] BCL3,[9] androgenskim receptorom,[10] endotelinskim receptorom tipa A[11] i PLA2G4A.[12]

Reference[уреди]

  1. Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G (1996). „Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator”. Virology. 216 (2): 357—66. doi:10.1006/viro.1996.0071. PMID 8607265. 
  2. 2,0 2,1 „Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa”. 
  3. Xiao, Hui; Chung Jin, Kao Hung-Ying, Yang Yu-Chung (2003). „Tip60 is a co-repressor for STAT3”. J. Biol. Chem. United States. 278 (13): 11197—204. doi:10.1074/jbc.M210816200. ISSN 0021-9258. PMID 12551922. 
  4. Hejna, James; Holtorf Megan, Hines Jennie, Mathewson Lauren, Hemphill Aaron, Al-Dhalimy Muhsen, Olson Susan B, Moses Robb E (2008). „Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway”. J. Biol. Chem. United States. 283 (15): 9844—51. doi:10.1074/jbc.M709076200. ISSN 0021-9258. PMC 2398728слободно за читање. PMID 18263878. 
  5. Gavaravarapu, S; Kamine J (2000). „Tip60 inhibits activation of CREB protein by protein kinase A”. Biochem. Biophys. Res. Commun. UNITED STATES. 269 (3): 758—66. doi:10.1006/bbrc.2000.2358. ISSN 0006-291X. PMID 10720489. 
  6. Nordentoft, Iver; Jørgensen Poul (2003). „The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor”. Biochem. J. England. 374 (Pt 1): 165—73. doi:10.1042/BJ20030087. ISSN 0264-6021. PMC 1223570слободно за читање. PMID 12737628. 
  7. Legube, Gaëlle; Linares Laetitia K, Lemercier Claudie, Scheffner Martin, Khochbin Saadi, Trouche Didier (2002). „Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation”. EMBO J. England. 21 (7): 1704—12. doi:10.1093/emboj/21.7.1704. ISSN 0261-4189. PMC 125958слободно за читање. PMID 11927554. 
  8. Frank, Scott R; Parisi Tiziana, Taubert Stefan, Fernandez Paula, Fuchs Miriam, Chan Ho-Man, Livingston David M, Amati Bruno (2003). „MYC recruits the TIP60 histone acetyltransferase complex to chromatin”. EMBO Rep. England. 4 (6): 575—80. doi:10.1038/sj.embor.embor861. ISSN 1469-221X. PMC 1319201слободно за читање. PMID 12776177. 
  9. Dechend, R; Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn F G, Scheidereit C, Leutz A (1999). „The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators”. Oncogene. ENGLAND. 18 (22): 3316—23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352. 
  10. Gaughan, Luke; Logan Ian R, Cook Susan, Neal David E, Robson Craig N (2002). „Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor”. J. Biol. Chem. United States. 277 (29): 25904—13. doi:10.1074/jbc.M203423200. ISSN 0021-9258. PMID 11994312. 
  11. Lee, H J; Chun M, Kandror K V (2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling”. J. Biol. Chem. United States. 276 (20): 16597—600. doi:10.1074/jbc.C000909200. ISSN 0021-9258. PMID 11262386. 
  12. Sheridan, A M; Force T, Yoon H J, O'Leary E, Choukroun G, Taheri M R, Bonventre J V (2001). „PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production”. Mol. Cell. Biol. United States. 21 (14): 4470—81. doi:10.1128/MCB.21.14.4470-4481.2001. ISSN 0270-7306. PMC 87107слободно за читање. PMID 11416127. 

Literatura[уреди]

  • Doyon Y, Côté J (2004). „The highly conserved and multifunctional NuA4 HAT complex.”. Curr. Opin. Genet. Dev. 14 (2): 147—54. doi:10.1016/j.gde.2004.02.009. PMID 15196461. 
  • Sapountzi V, Logan IR, Robson CN (2006). „Cellular functions of TIP60.”. Int. J. Biochem. Cell Biol. 38 (9): 1496—509. doi:10.1016/j.biocel.2006.03.003. PMID 16698308. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1-2): 171—4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1-2): 149—56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Yamamoto T, Horikoshi M (1998). „Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.”. J. Biol. Chem. 272 (49): 30595—8. doi:10.1074/jbc.272.49.30595. PMID 9388189. 
  • Kimura A, Horikoshi M (1999). „Tip60 acetylates six lysines of a specific class in core histones in vitro.”. Genes Cells. 3 (12): 789—800. doi:10.1046/j.1365-2443.1998.00229.x. PMID 10096020. 
  • Dechend R, Hirano F, Lehmann K; et al. (1999). „The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.”. Oncogene. 18 (22): 3316—23. doi:10.1038/sj.onc.1202717. PMID 10362352. 
  • Brady ME, Ozanne DM, Gaughan L; et al. (1999). „Tip60 is a nuclear hormone receptor coactivator.”. J. Biol. Chem. 274 (25): 17599—604. doi:10.1074/jbc.274.25.17599. PMID 10364196. 
  • Creaven M, Hans F, Mutskov V; et al. (1999). „Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat.”. Biochemistry. 38 (27): 8826—30. doi:10.1021/bi9907274. PMID 10393559. 
  • Sliva D, Zhu YX, Tsai S; et al. (1999). „Tip60 interacts with human interleukin-9 receptor alpha-chain.”. Biochem. Biophys. Res. Commun. 263 (1): 149—55. doi:10.1006/bbrc.1999.1083. PMID 10486269. 
  • Gavaravarapu S, Kamine J (2000). „Tip60 inhibits activation of CREB protein by protein kinase A.”. Biochem. Biophys. Res. Commun. 269 (3): 758—66. doi:10.1006/bbrc.2000.2358. PMID 10720489. 
  • Husi H, Ward MA, Choudhary JS; et al. (2000). „Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.”. Nat. Neurosci. 3 (7): 661—9. doi:10.1038/76615. PMID 10862698. 
  • Ikura T, Ogryzko VV, Grigoriev M; et al. (2000). „Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.”. Cell. 102 (4): 463—73. doi:10.1016/S0092-8674(00)00051-9. PMID 10966108. 
  • Ran Q, Pereira-Smith OM (2001). „Identification of an alternatively spliced form of the Tat interactive protein (Tip60), Tip60(beta).”. Gene. 258 (1-2): 141—6. doi:10.1016/S0378-1119(00)00410-8. PMID 11111051. 
  • Lee HJ, Chun M, Kandror KV (2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.”. J. Biol. Chem. 276 (20): 16597—600. doi:10.1074/jbc.C000909200. PMID 11262386. 
  • Hlubek F, Löhberg C, Meiler J; et al. (2001). „Tip60 is a cell-type-specific transcriptional regulator.”. J. Biochem. 129 (4): 635—41. PMID 11275565. 
  • Sheridan AM, Force T, Yoon HJ; et al. (2001). „PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.”. Mol. Cell. Biol. 21 (14): 4470—81. doi:10.1128/MCB.21.14.4470-4481.2001. PMC 87107слободно за читање. PMID 11416127. 
  • Cao X, Südhof TC (2001). „A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.”. Science. 293 (5527): 115—20. doi:10.1126/science.1058783. PMID 11441186. 
  • Legube G, Linares LK, Lemercier C; et al. (2002). „Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.”. EMBO J. 21 (7): 1704—12. doi:10.1093/emboj/21.7.1704. PMC 125958слободно за читање. PMID 11927554.