Holestarol-5,6-oksidna hidrolaza
| Holestarol-5,6-oksidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.3.2.11 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Holestarol-5,6-oksidna hidrolaza (EC 3.3.2.11, holestarol-epoksidna hidrolaza, ChEH) je enzim sa sistematskim imenom 5,6alfa-epoksi-5alfa-holestan-3beta-ol hidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 5,6alfa-epoksi-5alfa-holestan-3beta-ol + H2O 5alfa-holestan-3beta,5alfa,6beta-triol
- (2) 5,6beta-epoksi-5beta-holestan-3beta-ol + H2O 5alfa-holestan-3beta,5alfa,6beta-triol
Ovaj enzim deluje na širok opseg epoksida.
Reference[уреди | уреди извор]
- ^ Levin, W., Michaud, D.P., Thomas, P.E. and Jerina, D.M. (1983). „Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 α-oxide and certain xenobiotic alkene and arene oxides”. Arch. Biochem. Biophys. 220: 485—494. PMID 6401984.
- ^ Oesch, F., Timms, C.W., Walker, C.H., Guenthner, T.M., Sparrow, A., Watabe, T. and Wolf, C.R. (1984). „Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities”. Carcinogenesis. 5: 7—9. PMID 6690087.
- ^ Sevanian, A. & McLeod, L.L. (1986). „Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase”. J. Biol. Chem. 261: 54—59. PMID 3941086.
- ^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734.
- ^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- +cholesterol-5,6-oxide+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
