Iloperidon
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Fanapt, Fiapta, Zomaril |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Identifikatori | |
| CAS broj | 133454-47-4  |
| ATC kod | N05AX14 (WHO) |
| PubChem | CID 71360 |
| DrugBank | DB04946 |
| ChemSpider | 64459 |
| ChEMBL | CHEMBL14376 |
Iloperidon je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 426,481 Da.[1][2][3][4][5][6][7][8][9]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 5 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 8 |
| Particioni koeficijent[10] (ALogP) | 4,0 |
| Rastvorljivost[11] (logS, log(mol/L)) | -6,3 |
| Polarna površina[12] (PSA, Å2) | 64,8 |
Reference
[уреди | уреди извор]- ^ Strupczewski, J. T.; Bordeau, K. J.; Chiang, Y.; Glamkowski, E. J.; Conway, P. G.; Corbett, R.; Hartman, H. B.; Szewczak, M. R.; Wilmot, C. A.; Helsley, G. C. (1995). . „3-(Aryloxy)alkylpiperidinyl-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)”. Journal of Medicinal Chemistry. 38 (7): 1119—1131. PMID 7707315. doi:10.1021/jm00007a009.
- ^ Kongsamut, S.; Roehr, J. E.; Cai, J.; Hartman, H. B.; Weissensee, P.; Kerman, L. L.; Tang, L.; Sandrasagra, A. (1996). . „Iloperidone binding to human and rat dopamine and 5-HT receptors”. Eur J Pharmacol. 317 (2–3): 417—423. PMID 8997630. doi:10.1016/s0014-2999(96)00840-0.
- ^ Hesselink, J. M. (2002). . „Iloperidone (Novartis)”. Idrugs : The Investigational Drugs Journal. 5 (1): 84—90. PMID 12861482.
- ^ Hesselink, J. M. (1999). . „Iloperidone (Hoechst Marion Roussel Inc)”. Idrugs : The Investigational Drugs Journal. 2 (6): 584—590. PMID 16127622.
- ^ Szewczak, M. R.; Corbett, R.; Rush, D. K.; Wilmot, C. A.; Conway, P. G.; Strupczewski, J. T.; Cornfeldt, M. (1995). . „The pharmacological profile of iloperidone, a novel atypical antipsychotic agent”. J Pharmacol Exp Ther. 274 (3): 1404—1413. PMID 7562515. doi:10.1016/S0022-3565(25)10685-X.
- ^ Bobo, W. V. (2013). . „Asenapine, iloperidone and lurasidone: Critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults”. Expert Review of Clinical Pharmacology. 6 (1): 61—91. PMID 23272794. doi:10.1586/ecp.12.70.
- ^ Citrome, L. (2010). . „Iloperidone: Chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion”. Expert Opinion on Drug Metabolism & Toxicology. 6 (12): 1551—1564. PMID 21034370. doi:10.1517/17425255.2010.531259.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
