Kalikrein 8
(преусмерено са KLK8)
| Kalikrein 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.118 | ||||||||
| CAS broj | 171715-15-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kalikrein 8 (EC 3.4.21.118, KLK8, PRSS19, ljudski kalikrein 8, hK8, mK8, ovasin, tumor-asocirani diferenciono izraženi gen 14, TADG-14, NP, neuropsin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje amidnih supstrata koji slede bazne aminokiseline Arg ili Lys u P1 poziciji, sa preferencijom za Arg u odnosu na Lys
Ovaj enzim se aktivira odstranjivanjem N-terminalnog prepropeptida.
Reference[уреди | уреди извор]
- ^ Chen, Z.L., Yoshida, S., Kato, K., Momota, Y., Suzuki, J., Tanaka, T., Ito, J., Nishino, H., Aimoto, S., Kiyama, H. and Shiosaka, S. (1995). „Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus”. J. Neurosci. 15: 5088—5097. PMID 7623137.
- ^ Shimizu, C., Yoshida, S., Shibata, M., Kato, K., Momota, Y., Matsumoto, K., Shiosaka, T., Midorikawa, R., Kamachi, T., Kawabe, A. and Shiosaka, S. (1998). „Characterization of recombinant and brain neuropsin, a plasticity-related serine protease”. J. Biol. Chem. 273: 11189—11196. PMID 9556608.
- ^ Rajapakse, S., Ogiwara, K., Takano, N., Moriyama, A. and Takahashi, T. (2005). „Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins”. FEBS Lett. 579: 6879—6884. PMID 16337200.
- ^ Kishi, T., Cloutier, S.M., Kündig, C., Deperthes, D. and Diamandis, E.P. (2006). „Activation and enzymatic characterization of recombinant human kallikrein 8”. Biol. Chem. 387: 723—731. PMID 16800733.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Kallikrein+8 на US National Library of Medicine Medical Subject Headings (MeSH)
