Kanabinol

Из Википедије, слободне енциклопедије
Kanabinol
(IUPAC) ime
6,6,9-trimetil-3-pentil-benzo[c]hromen-1-ol
Klinički podaci
Identifikatori
CAS broj 521-35-7
ATC kod nije dodeljen
PubChem[1][2] 2543
ChemSpider[3] 2447
UNII 7UYP6MC9GH YesY
KEGG[4] C07580 YesY
ChEMBL[5] CHEMBL74415 YesY
Hemijski podaci
Formula C21H26O2 
Mol. masa 310,4319 g/mol
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 77 °C (171 °F)
Rastvorljivost u voda nerastvoran je u vodi,[6] rastvoran je u metanolu i etanolu[7] mg/mL (20 °C)
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Kanabinol (CBN) je slab psihoaktivni kanabinoid prisutan u Cannabis sativa i Cannabis indica.[8] On je takođe metabolit tetrahidrokanabinola (THC).[9] CBN deluje kao slab agonist CB1 receptora. On ima visok afinitet za CB2 receptore, mada niži nego THC.[10][11]

Vidi još[уреди]

Reference[уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG“. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Lide, David R. (2012). CRC Handbook of Chemistry and Physics. CRC Press. стр. 3-90. ISBN 978-1-4398-8049-4. 
  7. Biotrend: Cannabinol (PDF: 21 kB)
  8. Karniol IG, Shirakawa I, Takahashi RN, Knobel E, Musty RE (1975). „Effects of delta9-tetrahydrocannabinol and cannabinol in man“. Pharmacology 13 (6): 502–12. DOI:10.1159/000136944. PMID 1221432. 
  9. McCallum ND, Yagen B, Levy S, Mechoulam R (May 1975). „Cannabinol: a rapidly formed metabolite of delta-1- and delta-6-tetrahydrocannabinol“. Experientia 31 (5): 520–1. PMID 1140243. 
  10. Mahadevan A, Siegel C, Martin BR, Abood ME, Beletskaya I, Razdan RK (October 2000). „Novel cannabinol probes for CB1 and CB2 cannabinoid receptors“. Journal of Medicinal Chemistry 43 (20): 3778–85. DOI:10.1021/jm0001572. PMID 11020293. 
  11. Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC (1998). „Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors“. Life Sciences 63 (1): PL1–6. DOI:10.1016/S0024-3205(98)00238-0. PMID 9667767. 

Literatura[уреди]

Spoljašnje veze[уреди]

  • Erowid Compounds found in Cannabis sativa



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