С Википедије, слободне енциклопедије
Lamivudin Prodajno ime 3TC, Epivir, Epivir-HBV, Hepitec Drugs.com Monografija Način primene Oralno Poluvreme eliminacije 5 - 7 h Izlučivanje Renalno
CAS broj 134678-17-4 Y ATC kod J05AF05 (WHO PubChem CID 60825 DrugBank DB00709 Y ChemSpider 54812 Y KEGG C07065 Y ChEBI CHEBI:63577 Y ChEMBL CHEMBL141 Y Formula C 8 H 11 N 3 O 3 S Molarna masa 229,256
NC1=NC(=O)N(C=C1)[C@@H]1CS[C@H](CO)O1
InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
Y Key:JTEGQNOMFQHVDC-NKWVEPMBSA-N
Y
Tačka topljenja
Lamivudin je organsko jedinjenje , koje sadrži 8 atoma ugljenika i ima molekulsku masu od 229,256 Da .[1] [2] [3]
^ Fox Z, Dragsted UB, Gerstoft J, Phillips AN, Kjaer J, Mathiesen L, Youle M, Katlama C, Hill A, Bruun JN, Clumeck N, Dellamonica P, Lundgren JD: A randomized trial to evaluate continuation versus discontinuation of lamivudine in individuals failing a lamivudine-containing regimen: the COLATE trial. Antivir Ther. 2006;11(6):761-70. PMID 17310820
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs” . Nucleic Acids Res . 39 (Database issue): D1035—41. PMC 3013709 PMID 21059682 . doi :10.1093/nar/gkq1126 . ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets” . Nucleic acids research . 36 (Database issue): D901—6. PMC 2238889 PMID 18048412 . doi :10.1093/nar/gkm958 . ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods” . J. Phys. Chem. A . 102 : 3762—3772. doi :10.1021/jp980230o . ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices” . Chem Inf. Comput. Sci . 41 : 1488—1493. PMID 11749573 . doi :10.1021/ci000392t . ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties” . J. Med. Chem . 43 : 3714—3717. PMID 11020286 . doi :10.1021/jm000942e .
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. PMID 21059682. doi:10.1093/nar/gkq1126.
