Lijaza S-specifična sporna fotoprodukta
| Lijaza S-specifična sporna fotoprodukta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.15 | ||||||||
| CAS broj | 37290-70-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lijaza S-specifična sporna fotoprodukta (EC 4.1.99.15, SAM, SP lijaza, SPL, SplB, SplG) je enzim sa sistematskim imenom S-specifični sporski fotoprodukt pirimidin-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5S)-5,6-dihidro-5-(timidin-7-il)timidin (u DNK) + S-adenozil-L-metionin timidilil-(3'->5')-timidilat (u DNK) + 5'-dezoksiadenozin + L-metionin
Ovaj enzim sadrži gožđe-sumporni centar.
Reference[уреди | уреди извор]
- ^ Chandor, A., Berteau, O., Douki, T., Gasparutto, D., Sanakis, Y., Ollagnier-de-Choudens, S., Atta, M. and Fontecave, M. (2006). „Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis”. J. Biol. Chem. 281: 26922—26931. PMID 16829676.
- ^ Pieck, J.C., Hennecke, U., Pierik, A.J., Friedel, M.G. and Carell, T. (2006). „Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates”. J. Biol. Chem. 281: 36317—36326. PMID 16968710.
- ^ Mehl, R.A. & Begley, T.P. (1999). „Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct”. Org Lett. 1: 1065—1066. PMID 10825958.
- ^ Friedel, M.G., Berteau, O., Pieck, J.C., Atta, M., Ollagnier-de-Choudens, S., Fontecave, M. and Carell, T. (2006). „The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion”. Chem. Commun. (Camb.): 445—447. PMID 16493831.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- S-specific+spore+photoproduct+lyase на US National Library of Medicine Medical Subject Headings (MeSH)