Lizin-tRNK ligaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Lizin-tRNK ligaza
Lizin-tRNK ligaza
Identifikatori
EC broj	6.1.1.6
CAS broj	9031-26-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Lizin-tRNK ligaza (EC 6.1.1.6, lizil-tRNK sintetaza, lizil-transfer ribonukleat sintetaza, lizil-transfer RNK sintetaza, L-lizin-transfer RNK ligaza, lizin-tRNK sintetaza, lizinska translaza) je enzim sa sistematskim imenom L-lizin:tRNKLis ligaza (formira AMP).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-lizin + tRNK^Lys

\rightleftharpoons

AMP + difosfat + L-lizil-tRNK^Lys

Reference[уреди | уреди извор]

^ Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061—1067. PMID 13792726.
^ Chiumecka, V., von Tigerstrom, M., D'Obrenan, P. and Smith, C.J. (1969). „Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast”. J. Biol. Chem. 244: 5481—5488. PMID 4310598.
^ Lagerkvist, U., Rymo, L., Lindqvist, O. and Andersson, E. (1972). „Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast”. J. Biol. Chem. 247: 3897—3899. PMID 4555953.
^ Stern, R. & Mehler, A.H. (1965). „Lysyl-sRNA synthetase from Escherichia coli”. Biochem. Z. 342: 400—409. PMID 4284804.

Literatura[уреди | уреди извор]

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze[уреди | уреди извор]

Lysine---tRNA+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061—1067. PMID 13792726.

[2] Chiumecka, V., von Tigerstrom, M., D'Obrenan, P. and Smith, C.J. (1969). „Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast”. J. Biol. Chem. 244: 5481—5488. PMID 4310598.

[3] Lagerkvist, U., Rymo, L., Lindqvist, O. and Andersson, E. (1972). „Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast”. J. Biol. Chem. 247: 3897—3899. PMID 4555953.

[4] Stern, R. & Mehler, A.H. (1965). „Lysyl-sRNA synthetase from Escherichia coli”. Biochem. Z. 342: 400—409. PMID 4284804.

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п р у Enzimi: CO CS i CN ligaza (EC 6.1-6.3)
6.1: Ugljenik-kiseonik	Aminoacil tRNK sintetaza Alanin Arginin Asparagin Aspartat Cistein D-alanin-poli(fosforibitol) ligaza Glutamat Glutamin Glicin Histidin Izoleucin Leucin Lizin Metionin Fenilalanin Prolin Serin Treonin Triptofan Tirozin Valin
6.2: Ugljenik-sumpor	Sukcinil koenzim A sintetaza Acetil-KoA sintetaza Dugolančana-masna-kiselna-KoA ligaza
6.3: Ugljenik-azot	Glutamin sintetaza Ubikvitinska ligaza Kulin Von Hipel–Lindau tumor supresor UBE3A Mdm2 Kompleks promovisanja anafaze UBR1 Glutationska sintetaza CTP sintaza Adenilosukcinatna sintaza Argininosukcinatna sintaza Holokarboksilazna sintaza GMP sintaza Asparagin sintaza Karbamoil fosfat sintaza I II Glutamat-cisteinska ligaza

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6