Lobelin

Из Википедије, слободне енциклопедије
Lobelin
Lobeline structure.svg
IUPAC ime
2-((2R,6S)-6-((S)-2-Hidroksi-2-feniletil)-1-metilpiperidin-2-il)-1-feniletanon
Klinički podaci
Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 90-69-7 ДаY
ATCvet kod QV04CV01 (WHO)
PubChem CID 101616
ChemSpider 91814 НеН
UNII D0P25S3P81 ДаY
KEGG D02364 ДаY
ChEMBL CHEMBL15476 ДаY
Hemijski podaci
Formula C22H27NO2
Molarna masa 337,455
  (verify)

Lobelin je prirodni alkaloid prisutan u biljkama Lobelia inflata, Lobelia tupa, Lobelia cardinalis, Lobelia siphilitica, i Hippobroma longiflora. U svojoj čistoj formi on je beli amorfni prah koji je rastvoran u vodi.

Lobelin kao pomoćno sredstvo za potiskivanje želje za pušenjem,[1][2][3] a moguće je da primenljiv i kod drugih tipova zavisnosti, kao što je adikcija na amfetamin,[4][5] kokain[6] ili alkohol.[7]

Reference[уреди]

  1. Stead LF, Hughes JR (2012). „Lobeline for smoking cessation”. Cochrane Database Syst Rev. 2: CD000124. PMID 22336780. doi:10.1002/14651858.CD000124.pub2. 
  2. Marlow SP, Stoller JK. Smoking cessation. Respiratory Care. 2003 Dec;48(12):1238-56. PMID 14651764
  3. Buchhalter AR, Fant RV, Henningfield JE. Novel pharmacological approaches for treating tobacco dependence and withdrawal : current status. Drugs. 2008;68(8):1067-88. PMID 18484799
  4. Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT. Lobelane decreases methamphetamine self-administration in rats. European Journal of Pharmacology. 2007 Sep 24;571(1):33-8. doi:10.1016/j.ejphar.2007.06.003 PMID 17612524
  5. Eyerman DJ, Yamamoto BK. Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. Journal of Pharmacology and Experimental Therapeutics. 2005 Jan;312(1):160-9. PMID 15331654
  6. Polston JE, Cunningham CS, Rodvelt KR, Miller DK. Lobeline augments and inhibits cocaine-induced hyperactivity in rats. Life Sciences. 2006 Aug 1;79(10):981-90. PMID 16765386
  7. Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiology and Behavior. 2009 Jun 22;97(3-4):503-6. PMID 19268674