Metabotropni glutamatni receptor 8

Metabotropni glutamatni receptor 8
Metabotropni glutamatni receptor 8
Identifikatori
Simboli	GRM8; GLUR8; GPRC1H; MGLUR8; mGlu8
Vanjski ID	OMIM: 601116 MGI: 1351345 HomoloGene: 654 IUPHAR: mGlu8 GeneCards: GRM8 Gene
Ontologija gena
Molekularna funkcija	• aktivnost grupe III metabotropnih glutamatnih receptora; • aktivnost prenosa signala; • receptorska aktivnost; • aktivnost G protein spregnutog receptora; • aktivnost glutamatnog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • presinaptička membrana; • neuronska projekcija; • neuronsko ćelijsko telo;
Biološki proces	• signalni put G protein spregnutog receptora; • negativna regulacija aktivnosti adenilat ciklaze; • inhibicicija aktivnosti adenilat ciklaze signalnim putem G protein spregnutog glutamatog receptora; • vizuelna percepcija; • senzorna percepcija mirisa;
Ortolozi
Vrsta	Čovek
Entrez	2918
Ensembl	ENSG00000179603
UniProt	O00222
RefSeq (mRNA)	NM_000845.2
RefSeq (protein)	NP_000836.2
Lokacija (UCSC)	Chr 7:; 126.08 - 126.89 Mb
PubMed pretraga	[1]

Metabotropni glutamatni receptor 8 je protein koji je kod ljudi kodiran GRM8 genom.^[1]^[2]

Funkcija

Aminokiselina L-glutamat je glavni ekscitatorni neurotransmiter u centralnom nervnom sistemu koji aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalnih moždanih funkcija. Ona može da bude poremećena u mnogim neuropatološkim oboljenjima. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvence, mehanizma prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ovi receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok su u grupi III GRM4, GRM6, GRM7, i GRM8. Receptori grupe II i III su vezani za inhibiciju kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste. Alternativne splajsne varijante GRM8 su poznate, ali njihova svojstava nisu potpuno određena.^[2]

Ligandi

(S)-3,4-DCPG: agonist^[3]

Reference

^ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics. 31 (2): 230—3. PMID 8824806. doi:10.1006/geno.1996.0036.
^ ^а ^б „Entrez Gene: GRM8 glutamate receptor, metabotropic 8”.
^ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology. 40 (3): 311—8. PMID 11166323. doi:10.1016/S0028-3908(00)00169-6.

Literatura

Scherer SW; Soder S; Duvoisin RM; et al. (1997). „The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1”. Genomics. 44 (2): 232—6. PMID 9299241. doi:10.1006/geno.1997.4842.
Wu S; Wright RA; Rockey PK; et al. (1998). „Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells”. Brain Res. Mol. Brain Res. 53 (1–2): 88—97. PMID 9473604. doi:10.1016/S0169-328X(97)00277-5.
Malherbe P; Kratzeisen C; Lundstrom K; et al. (1999). „Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8”. Brain Res. Mol. Brain Res. 67 (2): 201—10. PMID 10216218. doi:10.1016/S0169-328X(99)00050-9.
Thomas NK; Wright RA; Howson PA; et al. (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology. 40 (3): 311—8. PMID 11166323. doi:10.1016/S0028-3908(00)00169-6.
Enz R (2002). „The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7”. FEBS Lett. 514 (2–3): 184—8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Tang Z, El Far O, Betz H, Scheschonka A (2006). „Pias1 interaction and sumoylation of metabotropic glutamate receptor 8”. J. Biol. Chem. 280 (46): 38153—9. PMID 16144832. doi:10.1074/jbc.M508168200.
Kobayashi Y; Akiyoshi J; Kanehisa M; et al. (2007). „Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder”. Psychiatr. Genet. 17 (1): 9. PMID 17167337. doi:10.1097/YPG.0b013e32801118bc.

Vidi još

Metabotropni glutamatni receptor

Spoljašnje veze

„Metabotropic Glutamate Receptors: mGlu₈”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[pmid8824806-1] Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics. 31 (2): 230—3. PMID 8824806. doi:10.1006/geno.1996.0036.

[entrez-2] а ^б „Entrez Gene: GRM8 glutamate receptor, metabotropic 8”.

[pmid11166323-3] Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology. 40 (3): 311—8. PMID 11166323. doi:10.1016/S0028-3908(00)00169-6.

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