N-Acetilaspartinska kiselina

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N-Acetilaspartinska kiselina
Stereo, skeletal formula of N-acetylaspartic acid (S)
Nazivi
IUPAC naziv
2-Acetamidobutandioinska kiselina[1]
Identifikacija
3D model (Jmol)
3DMet B00227
Bajlštajn 1726198 S
ChEBI
ChemSpider
ECHA InfoCard 100.012.403
EC broj 219-827-5
KEGG[2]
MeSH N-acetylaspartate
RTECS CI9098600
Svojstva
C6H9NO5
Molarna masa 175,14 g·mol−1
Agregatno stanje Bezbojni, transparentni kristali
log P −2.209
Kiselost (pKa) 3.142
Baznost (pKb) 10.855
Opasnosti
S-oznake S22, S24/25
Srodna jedinjenja
Srodne alkanoinske kiseline
Srodna jedinjenja
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

N-Acetilaspartic acid (N-acetilaspartat, NAA) je derivat aspartinske kiseline sa formulom C6H9NO5 i molekulskom težinom 175,139.

NAA je drugi po zastupljenosti neurotransmiter u mozgu, posle glutamatne aminokiseline. On je prisutan u mozgu odraslih osoba jedino u neuronima.[5] Sintetiše se u mitochondrijama[6] iz aspartinske kiseline i acetil-koenzimA A.

Reference[уреди]

  1. „N-acetylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005. Identification. Приступљено 8. 1. 2012. 
  2. Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  3. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  4. Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  5. Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991
  6. Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.

Literatura[уреди]

  • N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
  • Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; doi:10.1523/JNEUROSCI.0588-09.2009

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