N-acetilmuraminska kiselina 6-fosfatna eteraza
| N-acetilmuraminska kiselina 6-fosfatna eteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.126 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acetilmuraminska kiselina 6-fosfatna eteraza (EC 4.2.1.126, MurNAc-6-P eteraza, MurQ) je enzim sa sistematskim imenom (R)-laktat hidrolijaza (dodaje N-acetil-D-glukozamin 6-fosfat, formira N-acetilmuramat 6-fosfat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-laktat + N-acetil-D-glukozamin 6-fosfat N-acetilmuramat 6-fosfat + H2O
Ovaj enzim, zajedno sa EC 2.7.1.170, anhidro-N-acetilmuraminsko kiselinskom kinazom, je neophodan da bi proteobakterije iskoristile anhidro-N-acetilmuraminsku kiselinu.
Reference[уреди | уреди извор]
- ^ Jaeger, T., Arsic, M. and Mayer, C. (2005). „Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"”. J. Biol. Chem. 280: 30100—30106. PMID 15983044.
- ^ Uehara, T., Suefuji, K., Valbuena, N., Meehan, B., Donegan, M. and Park, J.T. (2005). „Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate”. J. Bacteriol. 187: 3643—3649. PMID 15901686.
- ^ Uehara, T., Suefuji, K., Jaeger, T., Mayer, C. and Park, J.T. (2006). „MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall”. J. Bacteriol. 188: 1660—1662. PMID 16452451.
- ^ Hadi, T., Dahl, U., Mayer, C. and Tanner, M.E. (2008). „Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling”. Biochemistry. 47: 11547—11558. PMID 18837509.
- ^ Jaeger, T. & Mayer, C. (2008). „N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism”. Cell. Mol. Life Sci. 65: 928—939. PMID 18049859.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- N-acetylmuramic+acid+6-phosphate+etherase на US National Library of Medicine Medical Subject Headings (MeSH)
