Nisko-specifična L-treoninska aldolaza
| Nisko-specifična L-treoninska aldolaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.1.2.48 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nisko-specifična L-treoninska aldolaza (EC 4.1.2.48, LtaE) je enzim sa sistematskim imenom L-treonin/L-allo-treonin acetaldehid-lijaza (formira glicin).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-treonin glicin + acetaldehid
- (2) L-allo-treonin glicin + acetaldehid
Za dejstvo ovog enzima je neophodan piridoksal fosfat.
Reference[уреди | уреди извор]
- ^ Yamada, H., Kumagai, H., Nagate, T. and Yoshida, H. (1970). „Crystalline threonine aldolase from Candida humicola”. Biochem. Biophys. Res. Commun. 39: 53—58. PMID 5438301.
- ^ Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H. (1972). „Threonine aldolase from Candida humicola. II. Purification, crystallization and properties”. Biochim. Biophys. Acta. 258: 779—790. PMID 5017702.
- ^ Liu, J.Q., Nagata, S., Dairi, T., Misono, H., Shimizu, S. and Yamada, H. (1997). „The GLY1 gene of Saccharomyces cerevisiae encodes a low-specific L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine–expression of the gene in Escherichia coli and purification and characterization of the enzyme”. Eur. J. Biochem. 245: 289—293. PMID 9151955.
- ^ Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. (1998). „Gene cloning, biochemical characterization and physiological role of a thermostable low-specificity L-threonine aldolase from Escherichia coli”. Eur. J. Biochem. 255: 220—226. PMID 9692922.
- ^ Kim, J., Kershner, J.P., Novikov, Y., Shoemaker, R.K. and Copley, S.D. (2010). „Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis”. Mol. Syst. Biol. 6: #436—436. PMID 21119630.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Low-specificity+L-threonine+aldolase на US National Library of Medicine Medical Subject Headings (MeSH)
