POLD3

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POLD3
PDB 1u76 EBI.jpg
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifikatori
AlijasiPOLD3
Spoljašnji IDHomoloGene: 38202 GeneCards: POLD3
Obrazac RNK izražavanja
PBB GE POLD3 212836 at fs.png
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006591
NM_001363597

n/a

RefSeq (protein)

NP_006582
NP_001350526

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Delta podjedinica 3 DNK polimeraze je enzim koji je kod ljudi kodiran POLD3 genom.[2][3] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije[уреди]

POLD3 formira interakcije sa PCNA.[4][5]

Reference[уреди]

  1. ^ „Human PubMed Reference:”. 
  2. ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (1999). „Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts”. Nucleic Acids Res. 27 (10): 2108—14. PMC 148430Slobodan pristup. PMID 10219083. doi:10.1093/nar/27.10.2108. 
  3. ^ „Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit”. 
  4. ^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2001). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200. 
  5. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 

Literatura[уреди]

  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1”. DNA Res. 1 (1): 27—35. PMID 7584026. doi:10.1093/dnares/1.1.27. 
  • Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). „DNA polymerase delta is involved in the cellular response to UV damage in human cells”. J. Biol. Chem. 269 (19): 13748—51. PMID 7910606. 
  • Longley MJ, Pierce AJ, Modrich P (1997). „DNA polymerase delta is required for human mismatch repair in vitro”. J. Biol. Chem. 272 (16): 10917—21. PMID 9099749. doi:10.1074/jbc.272.16.10917. 
  • Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry. 39 (24): 7245—54. PMID 10852724. doi:10.1021/bi0000871. 
  • Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200. 
  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  • Pohler JR, Otterlei M, Warbrick E (2006). „An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit”. BMC Mol. Biol. 6: 17. PMC 1187890Slobodan pristup. PMID 16000169. doi:10.1186/1471-2199-6-17. 
  • Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). „Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase”. Biochim. Biophys. Acta. 1764 (9): 1447—53. PMID 16935576. doi:10.1016/j.bbapap.2006.06.015. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635—48. PMID 17081983. doi:10.1016/j.cell.2006.09.026. 
  • Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). „Dynamics of human replication factors in the elongation phase of DNA replication”. Nucleic Acids Res. 35 (20): 6904—16. PMC 2175312Slobodan pristup. PMID 17932049. doi:10.1093/nar/gkm822.