PRE-084
 | |
| IUPAC ime | |
|---|---|
2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate | |
| Identifikatori | |
| CAS broj | 138847-85-5  |
| ATC kod | none |
| PubChem | CID 126402 |
| Hemijski podaci | |
| Formula | C19H27NO3 |
| Molarna masa | 317.422 g/mol |
| |
PRE-084 je agonist sigma receptor, koji je selektivan za σ1 tip. On je pokazao nootropno i antidepresivno dejstvo u studijama na životinjama, da može da služi kao sredstvo protiv kašlja.[1][2][3][4][5] PRE-084 povišava GDNF izražavanje.[6]
Reference[уреди | уреди извор]
- ^ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (1994). „PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice”. Pharmacology, Biochemistry, and Behavior. 49 (4): 859—69. PMID 7886099.
- ^ Maurice T (2001). „Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats”. European Journal of Pharmacology. 431 (2): 223—7. PMID 11728429.
- ^ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (2004). „Antitussive activity of sigma-1 receptor agonists in the guinea-pig”. British Journal of Pharmacology. 141 (2): 233—40. PMC 1574192
. PMID 14691051. doi:10.1038/sj.bjp.0705605.
- ^ Skuza G, Rogóz Z (2009). „Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice”. Pharmacological Reports : PR. 61 (6): 1179—83. PMID 20081254.
- ^ Hiranita T, Soto PL, Tanda G, Katz JL (2010). „Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine”. The Journal of Pharmacology and Experimental Therapeutics. 332 (2): 515—24. PMID 19892920. doi:10.1124/jpet.109.159236.
- ^ PMID 21332255
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
