Pentalenenska sintaza

Из Википедије, слободне енциклопедије
Pentalenenska sintaza
EC broj
CAS broj 90597-46-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pentalenenska sintaza (EC, pentalenenska sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira pentalenen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(2E,6E)-farnezil difosfat \rightleftharpoons pentalenen + difosfat

Ovaj enzim je prisutan u Streptomyces avermitilis.


  1. Cane, D.E. (1983). „Cell-free studies of monoterpene and sesquiterpene biosynthesis”. Biochem. Soc. Trans. 11: 510-515. PMID 6642060 
  2. Cane, D.E. and Tillman, A.M. (1983). „Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate”. J. Am. Chem. Soc. 105: 122-124 
  3. Cane, D.E., Sohng, J.K., Lamberson, C.R., Rudnicki, S.M., Wu, Z., Lloyd, M.D., Oliver, J.S. and Hubbard, B.R. (1994). „Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319”. Biochemistry 33: 5846-5857. PMID 8180213 
  4. Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. (1991). „Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332: 123-129. PMID 1678531 
  5. Lesburg, C.A., Zhai, G., Cane, D.E. and Christianson, D.W. (1997). „Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology”. Science 277: 1820-1824. PMID 9295272 
  6. Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. (2012). „Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”. J. Am. Chem. Soc. 134: 11369-11371. PMID 22738258 


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