RAR-srodni orfan receptor beta

RAR-vezani orfan receptor B
RAR-vezani orfan receptor B
	PDB slika bazirana na 1k4w.
Dostupne strukture
	1k4w, 1n4h, 1nq7
Identifikatori
Simboli	RORB; NR1F2; ROR-BETA; RZRB; bA133M9.1
Vanjski ID	OMIM: 601972 MGI: 1343464 HomoloGene: 38250 GeneCards: RORB Gene
Ontologija gena
Molekularna funkcija	• aktivnost transkripcionog faktora; • aktivnost steroidnog hormonskog receptora; • vezivanje proteina; • vezivanje jona cinka; • sekvenca-specifično DNK vezivanje; • vezivanje jona metala;
Celularna komponenta	• nukleus;
Biološki proces	• transkripcija; • regulacija transkripcije, DNK-zavisna; • razvoj multicelularnih organizama; • vizuelna percepcija; • ćelijski razvoj fotoreceptora oka; • pozitivna regulacija gen-specifične transkripcije; • respons na stimulus;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6096
Ensembl	ENSG00000198963
UniProt	Q92753
RefSeq (mRNA)	NM_006914
RefSeq (protein)	NP_008845
Lokacija (UCSC)	Chr 9:; 76.3 - 76.49 Mb
PubMed pretraga	[1]

RAR-srodni orfan receptor beta (ROR-beta), ili NR1F2 (nuklearni receptor potfamilije 1, grupe F, član 2), je nuklearni receptor kodiran genom RORB.

Protein kodiran ovim genom je član NR1 potfamilije nuklearnih hormonskih receptora. To je DNA-vezujući protein koji se može vezati kao monomer ili homodimer za elemente hormonskog odgovora uzvodno od nekoliko gena da bi pojačao ekspresiju tih gena. Specifične funkcije ovog proteina su nepoznate, ali se zna da ima interakciju sa NM23-2, nukleozid difosfat kinazom koja učestvuje u organogenezi i diferencijaciji.^[1]

Interakcije[уреди | уреди извор]

Za RAR-srodni orfan receptor beta pokazano da uspostavlja interakciju sa NME1.^[2]

Reference[уреди | уреди извор]

^ „Entrez Gene: RORB RAR-related orphan receptor B”.
^ Paravicini, G; Steinmayr M; et al. (1996). „The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily”. Biochem. Biophys. Res. Commun. UNITED STATES. 227 (1): 82—7. ISSN 0006-291X. PMID 8858107. doi:10.1006/bbrc.1996.1471. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

Literatura[уреди | уреди извор]

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Paravicini G, Steinmayr M, André E, Becker-André M (1996). „The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.”. Biochem. Biophys. Res. Commun. 227 (1): 82—7. PMID 8858107. doi:10.1006/bbrc.1996.1471.
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