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Relaksinu/insulinu-slična familija, peptidni receptor 1
PDB rendering based on 2jm4.
Dostupne strukture
Simboli RXFP1; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177
Vanjski ID OMIM606654 MGI2682211 HomoloGene11007 IUPHAR: RXFP1 GeneCards: RXFP1 Gene
Vrsta Čovek Miš
Entrez 59350 381489
Ensembl ENSG00000171509 ENSMUSG00000034009
UniProt Q9HBX9 n/a
RefSeq (mRNA) NM_021634 NM_212452
RefSeq (protein) NP_067647 NP_997617
Lokacija (UCSC) Chr 4:
159.66 - 159.79 Mb
Chr 3:
79.73 - 79.82 Mb
PubMed pretraga [1] [2]

RXFP1, relaksinu/insulinu-slična familija, peptidni receptor 1, je humani G-protein spregnuti receptor.[1]

Vidi još[уреди]


Dodatna literatura[уреди]

  • Bathgate RA; Ivell R; Sanborn BM; et al. (2005). „Receptors for relaxin family peptides.”. Ann. N. Y. Acad. Sci. 1041: 61—76. PMID 15956688. doi:10.1196/annals.1282.010. 
  • Bathgate RA; Ivell R; Sanborn BM; et al. (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.”. Pharmacol. Rev. 58 (1): 7—31. PMID 16507880. doi:10.1124/pr.58.1.9. 
  • Hsu SY; Kudo M; Chen T; et al. (2001). „The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.”. Mol. Endocrinol. 14 (8): 1257—71. PMID 10935549. doi:10.1210/me.14.8.1257. 
  • Bartsch O, Bartlick B, Ivell R (2001). „Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity.”. Mol. Hum. Reprod. 7 (9): 799—809. PMID 11517286. doi:10.1093/molehr/7.9.799. 
  • Hsu SY; Nakabayashi K; Nishi S; et al. (2002). „Activation of orphan receptors by the hormone relaxin.”. Science. 295 (5555): 671—4. PMID 11809971. doi:10.1126/science.1065654. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Sudo S; Kumagai J; Nishi S; et al. (2003). „H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.”. J. Biol. Chem. 278 (10): 7855—62. PMID 12506116. doi:10.1074/jbc.M212457200. 
  • Ivell R; Balvers M; Pohnke Y; et al. (2004). „Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates.”. Reprod. Biol. Endocrinol. 1: 114. PMC 293425Слободан приступ. PMID 14633277. doi:10.1186/1477-7827-1-114. 
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285. 
  • Luna JJ; Riesewijk A; Horcajadas JA; et al. (2004). „Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle.”. Mol. Hum. Reprod. 10 (2): 85—90. PMID 14742692. doi:10.1093/molehr/gah019. 
  • Bond CP; Parry LJ; Samuel CS; et al. (2004). „Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.”. J. Clin. Endocrinol. Metab. 89 (7): 3477—85. PMID 15240635. doi:10.1210/jc.2003-030798. 
  • Liu C; Chen J; Kuei C; et al. (2005). „Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.”. Mol. Pharmacol. 67 (1): 231—40. PMID 15465925. doi:10.1124/mol.104.006700. 
  • Scott DJ; Layfield S; Riesewijk A; et al. (2005). „Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7.”. Clin. Exp. Pharmacol. Physiol. 31 (11): 828—32. PMID 15566402. doi:10.1111/j.1440-1681.2004.04075.x. 
  • Büllesbach EE, Schwabe C (2005). „The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7.”. J. Biol. Chem. 280 (14): 14051—6. PMID 15695505. doi:10.1074/jbc.M500030200. 
  • Tang M, Mazella J, Zhu HH, Tseng L (2005). „Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells.”. Mol. Hum. Reprod. 11 (4): 237—43. PMID 15722441. doi:10.1093/molehr/gah149. 
  • Hopkins EJ, Bathgate RA, Gooley PR (2005). „The human LGR7 low-density lipoprotein class A module requires calcium for structure.”. Ann. N. Y. Acad. Sci. 1041: 27—34. PMID 15956684. doi:10.1196/annals.1282.006. 
  • Bond CP; Parry LJ; Samuel CS; et al. (2005). „Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.”. Ann. N. Y. Acad. Sci. 1041: 136—43. PMID 15956698. doi:10.1196/annals.1282.020. 
  • Halls ML, Bathgate RA, Summers RJ (2005). „Signal switching after stimulation of LGR7 receptors by human relaxin 2.”. Ann. N. Y. Acad. Sci. 1041: 288—91. PMID 15956719. doi:10.1196/annals.1282.042. 
  • Muda M; He C; Martini PG; et al. (2005). „Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.”. Mol. Hum. Reprod. 11 (8): 591—600. PMID 16051677. doi:10.1093/molehr/gah205. 

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