Receptor slobodnih masnih kiselina 1

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Receptor slobodnih masnih kiselina 1
Identifikatori
Simboli FFAR1; FFA1R; GPCR40; GPR40
Vanjski ID OMIM603820 MGI2684079 HomoloGene3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 2864 233081
Ensembl ENSG00000126266 ENSMUSG00000044453
UniProt O14842 Q76JU9
RefSeq (mRNA) NM_005303.2 NM_194057.2
RefSeq (protein) NP_005294.1 NP_918946.2
Lokacija (UCSC) Chr 19:
35.84 - 35.84 Mb
Chr 7:
31.65 - 31.65 Mb
PubMed pretraga [1] [2]

Receptor slobodnih masnih kiselina 1 (FFA1) je G protein spregnuti receptor kodiran ljudskim genom FFAR1.[1] On je u znatnoj meri izražen u ćelijama pankreasa, a u manjoj meri u materici i mozgu.[2]

Reference[уреди]

Literatura[уреди]

  • Brown AJ, Jupe S, Briscoe CP (2005). „A family of fatty acid binding receptors.”. DNA Cell Biol. 24 (1): 54—61. PMID 15684720. doi:10.1089/dna.2005.24.54. 
  • Sawzdargo M; George SR; Nguyen T; et al. (1997). „A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.”. Biochem. Biophys. Res. Commun. 239 (2): 543—7. PMID 9344866. doi:10.1006/bbrc.1997.7513. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Briscoe CP; Tadayyon M; Andrews JL; et al. (2003). „The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.”. J. Biol. Chem. 278 (13): 11303—11. PMID 12496284. doi:10.1074/jbc.M211495200. 
  • Kotarsky K; Nilsson NE; Flodgren E; et al. (2003). „A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.”. Biochem. Biophys. Res. Commun. 301 (2): 406—10. PMID 12565875. doi:10.1016/S0006-291X(02)03064-4. 
  • Itoh Y; Kawamata Y; Harada M; et al. (2003). „Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.”. Nature. 422 (6928): 173—6. PMID 12629551. doi:10.1038/nature01478. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Hardy S; St-Onge GG; Joly E; et al. (2005). „Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.”. J. Biol. Chem. 280 (14): 13285—91. PMID 15695516. doi:10.1074/jbc.M410922200. 
  • Ogawa T; Hirose H; Miyashita K; et al. (2005). „GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.”. Metab. Clin. Exp. 54 (3): 296—9. PMID 15736105. doi:10.1016/j.metabol.2004.09.008. 
  • Tomita T; Masuzaki H; Noguchi M; et al. (2006). „GPR40 gene expression in human pancreas and insulinoma.”. Biochem. Biophys. Res. Commun. 338 (4): 1788—90. PMID 16289108. doi:10.1016/j.bbrc.2005.10.161. 
  • Tomita T; Masuzaki H; Iwakura H; et al. (2006). „Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.”. Diabetologia. 49 (5): 962—8. PMID 16525841. doi:10.1007/s00125-006-0193-8. 
  • Stoddart LA, Brown AJ, Milligan G (2007). „Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.”. Mol. Pharmacol. 71 (4): 994—1005. PMID 17200419. doi:10.1124/mol.106.031534. 
  • Bartoov-Shifman R; Ridner G; Bahar K; et al. (2007). „Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.”. J. Biol. Chem. 282 (32): 23561—71. PMID 17525159. doi:10.1074/jbc.M702115200. 
  • Sum CS; Tikhonova IG; Neumann S; et al. (2007). „Identification of residues important for agonist recognition and activation in GPR40.”. J. Biol. Chem. 282 (40): 29248—55. PMID 17699519. doi:10.1074/jbc.M705077200. 

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